NUPG_SHIFL
ID NUPG_SHIFL Reviewed; 418 AA.
AC P0AFF5; P09452; P76653;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Nucleoside permease NupG {ECO:0000255|HAMAP-Rule:MF_02049};
GN Name=nupG {ECO:0000255|HAMAP-Rule:MF_02049};
GN OrderedLocusNames=SF2961, S3164;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Broad-specificity transporter of purine and pyrimidine
CC nucleosides. Transport is driven by a proton motive force.
CC {ECO:0000255|HAMAP-Rule:MF_02049}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_02049}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_02049}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family.
CC {ECO:0000255|HAMAP-Rule:MF_02049}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN44442.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAP18266.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE005674; AAN44442.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE014073; AAP18266.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_708735.1; NC_004337.2.
DR RefSeq; WP_001049791.1; NZ_WPGW01000067.1.
DR AlphaFoldDB; P0AFF5; -.
DR SMR; P0AFF5; -.
DR STRING; 198214.SF2961; -.
DR EnsemblBacteria; AAN44442; AAN44442; SF2961.
DR EnsemblBacteria; AAP18266; AAP18266; S3164.
DR GeneID; 1027502; -.
DR GeneID; 66673154; -.
DR KEGG; sfl:SF2961; -.
DR KEGG; sfx:S3164; -.
DR PATRIC; fig|198214.7.peg.3521; -.
DR HOGENOM; CLU_013133_1_2_6; -.
DR OrthoDB; 791272at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0015506; F:nucleoside:proton symporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.20; -; 2.
DR HAMAP; MF_02049; NupG; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004740; Nuc_H_symport.
DR InterPro; IPR033667; NupG.
DR Pfam; PF03825; Nuc_H_symport; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00889; 2A0110; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..418
FT /note="Nucleoside permease NupG"
FT /id="PRO_0000058006"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02049"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02049"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02049"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02049"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02049"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02049"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02049"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02049"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02049"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02049"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02049"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02049"
SQ SEQUENCE 418 AA; 46389 MW; 01337ECEFC369266 CRC64;
MNLKLQLKIL SFLQFCLWGS WLTTLGSYMF VTLKFDGASI GAVYSSLGIA AVFMPALLGI
VADKWLSAKW VYAICHTIGA ITLFMAAQVT TPEAMFLVIL INSFAYMPTL GLINTISYYR
LQNAGMDIVT DFPPIRIWGT IGFIMAMWVV SLSGFELSHM QLYIGAALSA ILVLFTLTLP
HIPVAKQQAN QSWTTLLGLD AFALFKNKRM AIFFIFSMLL GAELQITNMF GNTFLHSFDK
DPMFASSFIV QHASIIMSIS QISETLFILT IPFFLSRYGI KNVMMISIVA WILRFALFAY
GDPTPFGTVL LVLSMIVYGC AFDFFNISGS VFVEKEVSPA IRASAQGMFL MMTNGFGCIL
GGIVSGKVVE MYTQNGITDW QTVWLIFAGY SVVLAFAFMA MFKYKHVRVP TGTQTVSH
