NUPP_BACSU
ID NUPP_BACSU Reviewed; 348 AA.
AC O05254; Q795M0;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Guanosine ABC transporter permease protein NupP {ECO:0000305};
GN Name=nupP {ECO:0000303|PubMed:21926227}; Synonyms=yufP;
GN OrderedLocusNames=BSU31560;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9274030; DOI=10.1099/00221287-143-8-2769;
RA Oudega B., Koningstein G., Rodrigues L., de Sales Ramon M., Hilbert H.,
RA Duesterhoeft A., Pohl T.M., Weitzenegger T.;
RT "Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence
RT of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai).";
RL Microbiology 143:2769-2774(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION, SUBUNIT, AND INDUCTION.
RC STRAIN=168 / SMY;
RX PubMed=21926227; DOI=10.1128/jb.05899-11;
RA Belitsky B.R., Sonenshein A.L.;
RT "CodY-mediated regulation of guanosine uptake in Bacillus subtilis.";
RL J. Bacteriol. 193:6276-6287(2011).
CC -!- FUNCTION: Part of an ABC transporter complex involved in the uptake of
CC guanosine (PubMed:21926227). Responsible for the translocation of the
CC substrate across the membrane (Probable). May be a nucleoside
CC transporter of broad specificity but with various affinities for
CC different substrates (PubMed:21926227). {ECO:0000269|PubMed:21926227,
CC ECO:0000305}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NupO),
CC two transmembrane proteins (NupP and NupQ) and a solute-binding protein
CC (NupN). {ECO:0000305|PubMed:21926227}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Transcriptionally regulated by CodY.
CC {ECO:0000269|PubMed:21926227}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
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DR EMBL; Z93937; CAB07938.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15145.1; -; Genomic_DNA.
DR PIR; E70009; E70009.
DR RefSeq; NP_391034.1; NC_000964.3.
DR RefSeq; WP_003243735.1; NZ_JNCM01000033.1.
DR AlphaFoldDB; O05254; -.
DR STRING; 224308.BSU31560; -.
DR PaxDb; O05254; -.
DR EnsemblBacteria; CAB15145; CAB15145; BSU_31560.
DR GeneID; 937175; -.
DR KEGG; bsu:BSU31560; -.
DR PATRIC; fig|224308.179.peg.3421; -.
DR eggNOG; COG4603; Bacteria.
DR InParanoid; O05254; -.
DR OMA; FRMNLFN; -.
DR PhylomeDB; O05254; -.
DR BioCyc; BSUB:BSU31560-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR001851; ABC_transp_permease.
DR InterPro; IPR002229; RhesusRHD.
DR Pfam; PF02653; BPD_transp_2; 1.
DR PRINTS; PR00342; RHESUSRHD.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..348
FT /note="Guanosine ABC transporter permease protein NupP"
FT /id="PRO_0000359915"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 348 AA; 36844 MW; 960C3D451B483EC3 CRC64;
MVKRLSHLLV PLIAIILGLA AGALIMLVSG YSVASGYSAL WNGIFGEIYY VGETIRQITP
YILSGLAVAF AFRTGLFNIG VEGQLLVGWT AAVWVGTAFD GPAYIHLPLA LITAAAAGGL
WGFIPGILKA RFYVHEVIVT IMMNYIALHM TNYIISNVLT DHQDKTGKIH ESASLRSPFL
EQITDYSRLH LGIIVALLAA VIMWFIINKS TKGFELRAVG FNQHASQYAG MSVRKNIMTS
MLISGAFAGL AGAMEGLGTF EYAAVKGAFT GVGFDGIAVA LLGGNTAVGV VLAACLLGGL
KIGALNMPIE SGVPSEVVDI VIAIIILFVA SSYAIRFVMG KLKKKGAN
