NUPQ_BACSU
ID NUPQ_BACSU Reviewed; 319 AA.
AC O05255; Q795L9;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Guanosine ABC transporter permease protein NupQ {ECO:0000305};
GN Name=nupQ {ECO:0000303|PubMed:21926227}; Synonyms=yufQ;
GN OrderedLocusNames=BSU31570;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9274030; DOI=10.1099/00221287-143-8-2769;
RA Oudega B., Koningstein G., Rodrigues L., de Sales Ramon M., Hilbert H.,
RA Duesterhoeft A., Pohl T.M., Weitzenegger T.;
RT "Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence
RT of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai).";
RL Microbiology 143:2769-2774(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION, SUBUNIT, AND INDUCTION.
RC STRAIN=168 / SMY;
RX PubMed=21926227; DOI=10.1128/jb.05899-11;
RA Belitsky B.R., Sonenshein A.L.;
RT "CodY-mediated regulation of guanosine uptake in Bacillus subtilis.";
RL J. Bacteriol. 193:6276-6287(2011).
CC -!- FUNCTION: Part of an ABC transporter complex involved in the uptake of
CC guanosine (PubMed:21926227). Responsible for the translocation of the
CC substrate across the membrane (Probable). May be a nucleoside
CC transporter of broad specificity but with various affinities for
CC different substrates (PubMed:21926227). {ECO:0000269|PubMed:21926227,
CC ECO:0000305}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NupO),
CC two transmembrane proteins (NupP and NupQ) and a solute-binding protein
CC (NupN). {ECO:0000305|PubMed:21926227}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Transcriptionally regulated by CodY.
CC {ECO:0000269|PubMed:21926227}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
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DR EMBL; Z93937; CAB07939.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15146.1; -; Genomic_DNA.
DR PIR; F70009; F70009.
DR RefSeq; NP_391035.1; NC_000964.3.
DR RefSeq; WP_003228827.1; NZ_JNCM01000033.1.
DR AlphaFoldDB; O05255; -.
DR STRING; 224308.BSU31570; -.
DR PaxDb; O05255; -.
DR PRIDE; O05255; -.
DR EnsemblBacteria; CAB15146; CAB15146; BSU_31570.
DR GeneID; 937176; -.
DR KEGG; bsu:BSU31570; -.
DR PATRIC; fig|224308.179.peg.3422; -.
DR eggNOG; COG1079; Bacteria.
DR InParanoid; O05255; -.
DR OMA; MIFGNWM; -.
DR PhylomeDB; O05255; -.
DR BioCyc; BSUB:BSU31570-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR001851; ABC_transp_permease.
DR Pfam; PF02653; BPD_transp_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..319
FT /note="Guanosine ABC transporter permease protein NupQ"
FT /id="PRO_0000360517"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 319 AA; 33738 MW; 9C48EB4035454D74 CRC64;
MDIVQILSII VPATLVYAAP LILTALGGVF SERSGVVNIG LEGLMIIGAF TSVLFNLFFG
QELGAAAPWL SLLAAMAAGA LFSLIHAAAA ISFRADQTVS GVAINMLALG ATLFIVKLIY
GKAQTDKIPE PFYKTKIPGL GDIPVLGKIF FSDVYYTSIL AIALAFISWF ILFKTPFGLR
IRSVGEHPMA ADTMGINVYK MRYIGVMISG LFGGLGGGVY ASTIALDFTH STISGQGFIA
LAALVFGKWH PIGALGAALF FGFAQSLSII GSLLPLFKDI PNVYMLMAPY ILTILALTGF
IGRADAPKAN GVPYIKGKR
