ID   NUPR2_BOVIN             Reviewed;          98 AA.
AC   Q32PB4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Nuclear protein 2 {ECO:0000305};
DE   AltName: Full=Nuclear transcriptional regulator 1-like protein {ECO:0000250|UniProtKB:A6NF83};
DE   AltName: Full=Nuclear transcriptional regulator protein 2 {ECO:0000250|UniProtKB:A6NF83};
GN   Name=NUPR2 {ECO:0000250|UniProtKB:A6NF83};
GN   Synonyms=NUPR1L {ECO:0000250|UniProtKB:A6NF83};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional repressor by inhibiting gene
CC       expression at the NUPR1 promoter in a p53/TP53-dependent manner in
CC       cancer cells. Involved in the G1 cell cycle arrest, and in a decrease
CC       in cell viability and cell proliferation. Plays a role as a negative
CC       regulator of the protumoral factor NUPR1.
CC       {ECO:0000250|UniProtKB:A6NF83}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A6NF83}.
CC   -!- SIMILARITY: Belongs to the NUPR family. {ECO:0000305}.
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DR   EMBL; BC108184; AAI08185.1; -; mRNA.
DR   RefSeq; NP_001035664.1; NM_001040574.1.
DR   AlphaFoldDB; Q32PB4; -.
DR   SMR; Q32PB4; -.
DR   STRING; 9913.ENSBTAP00000042240; -.
DR   PaxDb; Q32PB4; -.
DR   GeneID; 614047; -.
DR   KEGG; bta:614047; -.
DR   CTD; 389493; -.
DR   eggNOG; KOG4319; Eukaryota.
DR   InParanoid; Q32PB4; -.
DR   OrthoDB; 1609352at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0009267; P:cellular response to starvation; ISS:UniProtKB.
DR   GO; GO:0045786; P:negative regulation of cell cycle; IBA:GO_Central.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR018792; NUPR1-like.
DR   PANTHER; PTHR17149; PTHR17149; 1.
DR   Pfam; PF10195; Phospho_p8; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Growth arrest; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..98
FT                   /note="Nuclear protein 2"
FT                   /id="PRO_0000346767"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          78..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..22
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   98 AA;  11522 MW;  41B6AD061968358A CRC64;
     MEPAAPTVQP RAQPPPPDVW PPVGSEEEFY DCPDYYYLRD FPACGAGRIN GRTRRERELR
     TNWLVPGGHE RKIAQKLLNS QRKRRQRQLQ PRPRTRLT