NUPR2_HUMAN
ID NUPR2_HUMAN Reviewed; 97 AA.
AC A6NF83;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Nuclear protein 2 {ECO:0000305};
DE AltName: Full=Nuclear transcriptional regulator 1-like protein {ECO:0000303|PubMed:25899918};
DE AltName: Full=Nuclear transcriptional regulator protein 2 {ECO:0000312|HGNC:HGNC:44164};
GN Name=NUPR2 {ECO:0000312|HGNC:HGNC:44164};
GN Synonyms=NUPR1L {ECO:0000303|PubMed:25899918};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION BY TP53.
RX PubMed=25899918; DOI=10.1002/jcp.25022;
RA Lopez M.B., Garcia M.N., Grasso D., Bintz J., Molejon M.I., Velez G.,
RA Lomberk G., Neira J.L., Urrutia R., Iovanna J.;
RT "Functional characterization of Nupr1L, a novel p53-regulated isoform of
RT the high-mobility group (HMG)-related protumoral protein Nupr1.";
RL J. Cell. Physiol. 230:2936-2950(2015).
CC -!- FUNCTION: Acts as a transcriptional repressor by inhibiting gene
CC expression at the NUPR1 promoter in a p53/TP53-dependent manner in
CC cancer cells (PubMed:25899918). Involved in the G1 cell cycle arrest,
CC and in a decrease in cell viability and cell proliferation
CC (PubMed:25899918). Plays a role as a negative regulator of the
CC protumoral factor NUPR1 (PubMed:25899918).
CC {ECO:0000269|PubMed:25899918}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25899918}.
CC -!- INDUCTION: Up-regulated by p53/TP53 in cancer cells (PubMed:25899918).
CC Up-regulated by DNA damage stimulus or starvation (PubMed:25899918).
CC {ECO:0000269|PubMed:25899918}.
CC -!- SIMILARITY: Belongs to the NUPR family. {ECO:0000305}.
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DR EMBL; AC006970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC043523; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS59058.1; -.
DR RefSeq; NP_001139184.1; NM_001145712.1.
DR AlphaFoldDB; A6NF83; -.
DR STRING; 9606.ENSP00000455442; -.
DR PhosphoSitePlus; A6NF83; -.
DR BioMuta; NUPR2; -.
DR MassIVE; A6NF83; -.
DR PaxDb; A6NF83; -.
DR PeptideAtlas; A6NF83; -.
DR PRIDE; A6NF83; -.
DR DNASU; 389493; -.
DR Ensembl; ENST00000329309.4; ENSP00000455442.1; ENSG00000185290.4.
DR GeneID; 389493; -.
DR KEGG; hsa:389493; -.
DR MANE-Select; ENST00000329309.4; ENSP00000455442.1; NM_001145712.2; NP_001139184.1.
DR UCSC; uc003tsb.4; human.
DR CTD; 389493; -.
DR DisGeNET; 389493; -.
DR GeneCards; NUPR2; -.
DR HGNC; HGNC:44164; NUPR2.
DR HPA; ENSG00000185290; Tissue enriched (testis).
DR neXtProt; NX_A6NF83; -.
DR OpenTargets; ENSG00000185290; -.
DR VEuPathDB; HostDB:ENSG00000185290; -.
DR eggNOG; KOG4319; Eukaryota.
DR GeneTree; ENSGT00530000064242; -.
DR HOGENOM; CLU_180450_1_0_1; -.
DR InParanoid; A6NF83; -.
DR OMA; FEEAHYD; -.
DR OrthoDB; 1609352at2759; -.
DR PhylomeDB; A6NF83; -.
DR PathwayCommons; A6NF83; -.
DR BioGRID-ORCS; 389493; 27 hits in 1053 CRISPR screens.
DR GenomeRNAi; 389493; -.
DR Pharos; A6NF83; Tbio.
DR PRO; PR:A6NF83; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A6NF83; protein.
DR Bgee; ENSG00000185290; Expressed in left testis and 85 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IDA:UniProtKB.
DR GO; GO:0009267; P:cellular response to starvation; IDA:UniProtKB.
DR GO; GO:0045786; P:negative regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; IDA:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR DisProt; DP01159; -.
DR InterPro; IPR018792; NUPR1-like.
DR PANTHER; PTHR17149; PTHR17149; 1.
DR Pfam; PF10195; Phospho_p8; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Growth arrest; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..97
FT /note="Nuclear protein 2"
FT /id="PRO_0000346768"
FT REGION 76..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..97
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 97 AA; 11356 MW; 3B14AFD233C5971A CRC64;
MEAPAERALP RLQALARPPP PISYEEELYD CLDYYYLRDF PACGAGRSKG RTRREQALRT
NWPAPGGHER KVAQKLLNGQ RKRRQRQLHP KMRTRLT
