NUPR2_MOUSE
ID NUPR2_MOUSE Reviewed; 102 AA.
AC Q497P3; Q3UXQ0; Q9D923;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Nuclear protein 2 {ECO:0000305};
DE AltName: Full=Nuclear transcriptional regulator 1-like protein {ECO:0000250|UniProtKB:A6NF83};
DE AltName: Full=Nuclear transcriptional regulator protein 2 {ECO:0000250|UniProtKB:A6NF83};
GN Name=Nupr2 {ECO:0000250|UniProtKB:A6NF83};
GN Synonyms=Nupr1l {ECO:0000250|UniProtKB:A6NF83};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Muellerian duct, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acts as a transcriptional repressor by inhibiting gene
CC expression at the NUPR1 promoter in a p53/TP53-dependent manner in
CC cancer cells. Involved in the G1 cell cycle arrest, and in a decrease
CC in cell viability and cell proliferation of pancreatic cancer cells.
CC Plays a role as a negative regulator of the protumoral factor NUPR1.
CC {ECO:0000250|UniProtKB:A6NF83}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A6NF83}.
CC -!- SIMILARITY: Belongs to the NUPR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB25026.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK007417; BAB25026.1; ALT_FRAME; mRNA.
DR EMBL; AK135384; BAE22513.1; -; mRNA.
DR EMBL; BC100444; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS51654.1; -.
DR RefSeq; NP_081192.2; NM_026916.3.
DR RefSeq; XP_006504556.1; XM_006504493.3.
DR AlphaFoldDB; Q497P3; -.
DR STRING; 10090.ENSMUSP00000137364; -.
DR PhosphoSitePlus; Q497P3; -.
DR PaxDb; Q497P3; -.
DR PRIDE; Q497P3; -.
DR ProteomicsDB; 293783; -.
DR DNASU; 69034; -.
DR Ensembl; ENSMUST00000178355; ENSMUSP00000137364; ENSMUSG00000095789.
DR Ensembl; ENSMUST00000194521; ENSMUSP00000142125; ENSMUSG00000095789.
DR Ensembl; ENSMUST00000195766; ENSMUSP00000141660; ENSMUSG00000095789.
DR GeneID; 69034; -.
DR KEGG; mmu:69034; -.
DR UCSC; uc008ztp.2; mouse.
DR CTD; 69034; -.
DR MGI; MGI:1923099; Nupr1l.
DR VEuPathDB; HostDB:ENSMUSG00000095789; -.
DR eggNOG; KOG4319; Eukaryota.
DR GeneTree; ENSGT00530000064242; -.
DR HOGENOM; CLU_180450_1_0_1; -.
DR InParanoid; Q497P3; -.
DR OMA; FEEAHYD; -.
DR OrthoDB; 1609352at2759; -.
DR PhylomeDB; Q497P3; -.
DR TreeFam; TF339452; -.
DR BioGRID-ORCS; 69034; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Nupr1l; mouse.
DR PRO; PR:Q497P3; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q497P3; protein.
DR Bgee; ENSMUSG00000095789; Expressed in spermatid and 70 other tissues.
DR Genevisible; Q497P3; MM.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR GO; GO:0009267; P:cellular response to starvation; ISS:UniProtKB.
DR GO; GO:0045786; P:negative regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR018792; NUPR1-like.
DR PANTHER; PTHR17149; PTHR17149; 1.
DR Pfam; PF10195; Phospho_p8; 1.
PE 3: Inferred from homology;
KW Cell cycle; Growth arrest; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..102
FT /note="Nuclear protein 2"
FT /id="PRO_0000346769"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 85
FT /note="Q -> H (in Ref. 1; BAE22513)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 102 AA; 11767 MW; F55DB25E167BDCDA CRC64;
MDPPTRPSVS GPRTRARPPP PEALPTVGFE EEVYDCLDYY YLRDFPASGA GRSKGRTRRE
QQLRTNYPVP GGHERKVAQI LLNGQRKRRQ RQLQPRPRTR LA
