ID   NUP_CANAL               Reviewed;         406 AA.
AC   Q5AGW8; A0A1D8PQV9; Q3MPI4;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Purine nucleoside permease {ECO:0000303|PubMed:9802205};
DE   Flags: Precursor;
GN   Name=NUP {ECO:0000303|PubMed:9802205}; Synonyms=NUP32;
GN   OrderedLocusNames=CAALFM_C701560CA; ORFNames=CaO19.13923, CaO19.6570;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   FUNCTION, AND ACTIVITY REGULATION.
RX   PubMed=9802205;
RX   DOI=10.1002/(sici)1097-0061(1998100)14:14<1257::aid-yea326>3.3.co;2-y;
RA   Detke S.;
RT   "Cloning of the Candida albicans nucleoside transporter by complementation
RT   of nucleoside transport-deficient Saccharomyces.";
RL   Yeast 14:1257-1265(1998).
RN   [5]
RP   PREDICTION AS A SUBSTRATE FOR KEX2 CLEAVAGE.
RX   PubMed=12419804; DOI=10.1074/jbc.m209713200;
RA   Newport G., Kuo A., Flattery A., Gill C., Blake J.J., Kurtz M.B.,
RA   Abruzzo G.K., Agabian N.;
RT   "Inactivation of Kex2p diminishes the virulence of Candida albicans.";
RL   J. Biol. Chem. 278:1713-1720(2003).
CC   -!- FUNCTION: Nucleoside permease that transports adenosine and guanosine.
CC       Does not show any transport activities towards cytidine, adenine,
CC       guanine, uridine, and uracil. {ECO:0000269|PubMed:9802205}.
CC   -!- ACTIVITY REGULATION: Mammalian nucleoside transport inhibitors
CC       dipyridamole and NBMPR inhibit adenosine transport by NUP.
CC       {ECO:0000269|PubMed:9802205}.
CC   -!- PTM: Predicted to be a substrate for cleavage by KEX2.
CC   -!- SIMILARITY: Belongs to the NUP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP017629; AOW30522.1; -; Genomic_DNA.
DR   RefSeq; XP_721406.1; XM_716313.1.
DR   AlphaFoldDB; Q5AGW8; -.
DR   STRING; 237561.Q5AGW8; -.
DR   GeneID; 3637041; -.
DR   KEGG; cal:CAALFM_C701560CA; -.
DR   CGD; CAL0000196928; NUP.
DR   VEuPathDB; FungiDB:C7_01560C_A; -.
DR   eggNOG; ENOG502QQPU; Eukaryota.
DR   HOGENOM; CLU_031475_0_1_1; -.
DR   InParanoid; Q5AGW8; -.
DR   OMA; GINTKGP; -.
DR   OrthoDB; 760224at2759; -.
DR   Proteomes; UP000000559; Chromosome 7.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0015506; F:nucleoside:proton symporter activity; IDA:CGD.
DR   GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR   GO; GO:0015858; P:nucleoside transport; IDA:CGD.
DR   Gene3D; 3.40.50.1580; -; 1.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   InterPro; IPR009486; Pur_nuclsid_perm.
DR   PANTHER; PTHR38643; PTHR38643; 1.
DR   Pfam; PF06516; NUP; 1.
DR   PIRSF; PIRSF013171; Pur_nuclsid_perm; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Signal; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..406
FT                   /note="Purine nucleoside permease"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000431101"
SQ   SEQUENCE   406 AA;  44863 MW;  5A93C353A2886341 CRC64;
     MKLSTLFTLA TTISTLTTFT IASPVVVVEK RAINETALAE DIPTTKNNHA QTSYGKPFAI
     YQPKAFIISM FSLERDPWLK AMDFVHNITI PGLSPVYPDI HCTTNYTICQ ITTGEGEINA
     ASSISALTLN PLFDLTKTYF LVGGIAGGEP NYTTIGGVTF AKYAVQVGLE YQLAYEDYHK
     TNPDWISGYI PYGTDDQNTY PGNVYGTEVF EVNEKLRDRA VELASKVHLN NGTEGNAKFR
     KLYNETAAQG LPKVVKCDSL TSDNYFTGNV LNDYFANFTL LMTNGSATYC STAQEDNATL
     EVMTRLAKHG LVDYDRIMIM RTISDFSRPP PSMSAYEYFF NRSDGGISAS LENLVIAGTP
     IIHDIVQNWD KIYESGEKYS SKNYVGDIFA TLGGKPDFGK ESFDTA