ID   NUP_CANAX               Reviewed;         406 AA.
AC   O93844;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Purine nucleoside permease {ECO:0000303|PubMed:9802205};
DE   Flags: Precursor;
GN   Name=NUP {ECO:0000303|PubMed:9802205};
OS   Candida albicans (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5476;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND ACTIVITY REGULATION.
RX   PubMed=9802205;
RX   DOI=10.1002/(sici)1097-0061(1998100)14:14<1257::aid-yea326>3.3.co;2-y;
RA   Detke S.;
RT   "Cloning of the Candida albicans nucleoside transporter by complementation
RT   of nucleoside transport-deficient Saccharomyces.";
RL   Yeast 14:1257-1265(1998).
CC   -!- FUNCTION: Nucleoside permease that transports adenosine and guanosine.
CC       Does not show any transport activities towards cytidine, adenine,
CC       guanine, uridine, and uracil. {ECO:0000269|PubMed:9802205}.
CC   -!- ACTIVITY REGULATION: Mammalian nucleoside transport inhibitors
CC       dipyridamole and NBMPR inhibit adenosine transport by NUP.
CC       {ECO:0000269|PubMed:9802205}.
CC   -!- SIMILARITY: Belongs to the NUP family. {ECO:0000305}.
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DR   EMBL; AF016246; AAC64324.1; -; Genomic_DNA.
DR   AlphaFoldDB; O93844; -.
DR   VEuPathDB; FungiDB:C7_01560C_A; -.
DR   VEuPathDB; FungiDB:CAWG_05507; -.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 3.40.50.1580; -; 1.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   InterPro; IPR009486; Pur_nuclsid_perm.
DR   PANTHER; PTHR38643; PTHR38643; 1.
DR   Pfam; PF06516; NUP; 1.
DR   PIRSF; PIRSF013171; Pur_nuclsid_perm; 1.
PE   3: Inferred from homology;
KW   Signal; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..406
FT                   /note="Purine nucleoside permease"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000431100"
SQ   SEQUENCE   406 AA;  44832 MW;  F6205B7274850496 CRC64;
     MKLSTLFTLA TTISTLTTFT IASPVVVVEK RAINETALAE DIPTTKNNHA QASYGKPFAI
     YQPKAFIISM FSLERDPWLK AMDFVHNITI PGLSPVYPDI HCTTNYTICQ ITTGEGEINA
     ASSISALTLN PLFDLTKTYF LVGGIAGGEP NYTTIGGVTF AKYAVQVGLE YQLAYEDYHK
     TNPDWISGYI PYGTDDQNTY PGNVYGTEVF EVNEKLRDRA VELASKVHLN NGTEGNAKFR
     KLYNETAAQG LPKVVKCDSL TSDNYFTGNV LNDYFANFTL LMTNGSATYC STAQEDNATL
     EVMTRLAKHG LVDYDRIMIM RTISDFSRPP PSMSAYEYFF NRSDGGISAS LENLVIAGTP
     IIHDIVQNWD KIYKSGEKYS SKNYVGDIFA TLGGKPDFGK ESFDTA