ID   NUP_SCHPO               Reviewed;         348 AA.
AC   O74493;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Probable purine nucleoside permease C285.05 {ECO:0000250|UniProtKB:Q5AGW8};
DE   Flags: Precursor;
GN   ORFNames=SPCC285.05 {ECO:0000312|PomBase:SPCC285.05};
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Probable nucleoside permease that transports adenosine and
CC       guanosine. {ECO:0000250|UniProtKB:Q5AGW8}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the NUP family. {ECO:0000305}.
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DR   EMBL; CU329672; CAA20844.1; -; Genomic_DNA.
DR   PIR; T41251; T41251.
DR   RefSeq; NP_588334.1; NM_001023325.2.
DR   AlphaFoldDB; O74493; -.
DR   SMR; O74493; -.
DR   BioGRID; 275900; 6.
DR   STRING; 4896.SPCC285.05.1; -.
DR   MaxQB; O74493; -.
DR   PaxDb; O74493; -.
DR   EnsemblFungi; SPCC285.05.1; SPCC285.05.1:pep; SPCC285.05.
DR   GeneID; 2539334; -.
DR   KEGG; spo:SPCC285.05; -.
DR   PomBase; SPCC285.05; -.
DR   VEuPathDB; FungiDB:SPCC285.05; -.
DR   eggNOG; ENOG502QQPU; Eukaryota.
DR   HOGENOM; CLU_031475_0_1_1; -.
DR   InParanoid; O74493; -.
DR   OMA; GINTKGP; -.
DR   PhylomeDB; O74493; -.
DR   PRO; PR:O74493; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0016021; C:integral component of membrane; IC:PomBase.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0015211; F:purine nucleoside transmembrane transporter activity; ISM:PomBase.
DR   GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1580; -; 1.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   InterPro; IPR009486; Pur_nuclsid_perm.
DR   PANTHER; PTHR38643; PTHR38643; 1.
DR   Pfam; PF06516; NUP; 1.
DR   PIRSF; PIRSF013171; Pur_nuclsid_perm; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Reference proteome; Signal; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..348
FT                   /note="Probable purine nucleoside permease C285.05"
FT                   /id="PRO_0000372355"
SQ   SEQUENCE   348 AA;  38139 MW;  D4D44AA7E5B4A52A CRC64;
     MLFLKLVASV LALMTIVPAQ AGLIGKRSVF KPKVMIINMF SLEANAWLSQ MDDLYANNIT
     VVGLNRLYPQ VHCNTQQTIC QMTTGEGKSN AASSIMALTL SPKFDLTETF FLISGIAGIN
     PYAASLGSVG VARFAVDIDL INSVDLRELP SYFQSSGWEI DTDPYENGSS NEIVYPESMP
     YQTNLYELNN TLITAAMEII KDVVLEDNEK AASYRKLYNE SAARRPPFIT QCDTATGDNY
     WAGTYMGDFV SNITNVLTNS TGHYCTTQQE DNASLTALTR ASFDGLVNIN RVVIMRSGSD
     FDRGAGNITA LANLLNSTGH VSSLACDNLY HAGAPLIDHI VNHWSYWT