ID   NUR1_ASHGO              Reviewed;         589 AA.
AC   Q759K4;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Nuclear rim protein 1;
GN   Name=NUR1; OrderedLocusNames=ADR273C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Member of a perinuclear network that controls recombination
CC       at multiple loci to maintain genome stability. Required for rDNA repeat
CC       stability (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUR1 family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS52193.2; -; Genomic_DNA.
DR   RefSeq; NP_984369.2; NM_209722.2.
DR   AlphaFoldDB; Q759K4; -.
DR   STRING; 33169.AAS52193; -.
DR   PRIDE; Q759K4; -.
DR   EnsemblFungi; AAS52193; AAS52193; AGOS_ADR273C.
DR   GeneID; 4620531; -.
DR   KEGG; ago:AGOS_ADR273C; -.
DR   eggNOG; ENOG502S7S0; Eukaryota.
DR   HOGENOM; CLU_033252_0_0_1; -.
DR   InParanoid; Q759K4; -.
DR   OMA; IKPNYHK; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043007; P:maintenance of rDNA; IBA:GO_Central.
DR   GO; GO:0007096; P:regulation of exit from mitosis; IBA:GO_Central.
DR   InterPro; IPR018819; Nur1/Mug154.
DR   PANTHER; PTHR28293; PTHR28293; 1.
DR   Pfam; PF10332; DUF2418; 1.
PE   3: Inferred from homology;
KW   Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..589
FT                   /note="Nuclear rim protein 1"
FT                   /id="PRO_0000409027"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          438..526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          559..589
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..493
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        498..520
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        559..577
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   589 AA;  67521 MW;  4E252F1FA6E2052F CRC64;
     MPKHHTFATK LEDLVLTSMS FRMSKHQAHP IEPEDVIREE SEDFYSDEEE YKETWSRWAL
     QLLSSSPYDL YLIVNENFES INWDLKAKTL ARPLGGTMTF LFFTVRLLQD NVIKPNYHKI
     NRTTDGFDFS RSATLREYDY FSKYQHGASW SSANWRVNSL SILDTLLKCL YILLLVSNSV
     LTYKFLFGYF LKYSLFHSAQ PPASNNLTKK SLHDLAYRSA TDVSRGSLWT LIRYTFFQRG
     RVQEEKPTDE FYYEIKKWCP SSFLTALFAS FPPISVWFMA FSDITFVSLL PVILTQYLFW
     YVIFDCYEDR IKDELAIFKG MAAEYNNKVM KPKLSAQTQD AMVDATMYGQ EFVQFYPSYS
     TARSGVFITH SLCGDVIKEK YNQRTKAFED IPTGSHSQNI IRYSRNERLY HSVFPQNPLK
     KINGAAMSVN PMSFNRSPTY GGRYGTPPSR SHGSGQTYSS TSAPTSPMLK NRRAIPTDHS
     TGGNISGGNY VEYTSNDVHG EPPRRHSTSP LKRDITSSAG REDNHLAFGV NSPNIRSRTV
     DVKKNLHTHT TVVCPKSDLD TSQLSSKQSS ISPFKLSRRG SIESRPPFR