ID   NUR1_KLULA              Reviewed;         546 AA.
AC   Q6CKY2;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Nuclear rim protein 1;
GN   Name=NUR1; OrderedLocusNames=KLLA0F07205g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Member of a perinuclear network that controls recombination
CC       at multiple loci to maintain genome stability. Required for rDNA repeat
CC       stability (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUR1 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98115.1; -; Genomic_DNA.
DR   RefSeq; XP_455407.1; XM_455407.1.
DR   AlphaFoldDB; Q6CKY2; -.
DR   STRING; 28985.XP_455407.1; -.
DR   EnsemblFungi; CAG98115; CAG98115; KLLA0_F07205g.
DR   GeneID; 2895974; -.
DR   KEGG; kla:KLLA0_F07205g; -.
DR   eggNOG; ENOG502S7S0; Eukaryota.
DR   HOGENOM; CLU_033252_0_0_1; -.
DR   InParanoid; Q6CKY2; -.
DR   OMA; IKPNYHK; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018819; Nur1/Mug154.
DR   PANTHER; PTHR28293; PTHR28293; 1.
DR   Pfam; PF10332; DUF2418; 1.
PE   3: Inferred from homology;
KW   Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..546
FT                   /note="Nuclear rim protein 1"
FT                   /id="PRO_0000409029"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          405..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          505..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        520..534
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   546 AA;  64087 MW;  DC7F07417145E331 CRC64;
     MAFWRNRHES PAISQERSPS PDRFQNSEDI REDNNNYNED EKLGWFASFM GMFSLPYDWY
     LSINEDIAVI DWDSKSNSVA WPLGNVLTFL FFSVRLLQDN VIAPNINKLT HSDDAFDFSK
     SKNLQKYDYF QQYGGSASSS ENLYYKMLRQ LHRLFYLLTV LLLITNISVT YRYLFAHFQT
     YSIFYWKTVP KSKNVTKKSL HDLNHTYVED AKRDSLWGMI KYLLFNGSHD DETNRAHYYE
     LRKWTPSRFL TSFFVSFSPI AFCFLWMTDV TFKTLIPIII HQYVLWFIVI DRYEQKLKDE
     QILSMSSVAE LNSKVIQPKM NVLKQDAMVD ATPYNDGIVY FYPAYTTTRS HVFATHTLSG
     KLSKEKYNPR TDSFEDANSQ RTENYVRFSY HHPKSINGAY VRESYPSRQH SPRLSPSRYS
     HLQSGNTPSA PSTPLLIPSQ QPHFDHSMLA NASRNHNISE RRNSHSPIKQ HFANRLLNYP
     DETNDSIPDV SDDRFRMDDR FRRGRQGYFN RSPDINSGTL HYDDGDDDDN RISKSPFRNS
     SSSPFR