ID   NUR1_LACTC              Reviewed;         592 AA.
AC   C5E3S7;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Nuclear rim protein 1;
GN   Name=NUR1; OrderedLocusNames=KLTH0H15994g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Member of a perinuclear network that controls recombination
CC       at multiple loci to maintain genome stability. Required for rDNA repeat
CC       stability (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUR1 family. {ECO:0000305}.
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DR   EMBL; CU928180; CAR30688.1; -; Genomic_DNA.
DR   RefSeq; XP_002556550.1; XM_002556504.1.
DR   AlphaFoldDB; C5E3S7; -.
DR   STRING; 559295.C5E3S7; -.
DR   PRIDE; C5E3S7; -.
DR   EnsemblFungi; CAR30688; CAR30688; KLTH0H15994g.
DR   GeneID; 8294916; -.
DR   KEGG; lth:KLTH0H15994g; -.
DR   eggNOG; ENOG502S7S0; Eukaryota.
DR   HOGENOM; CLU_033252_0_0_1; -.
DR   InParanoid; C5E3S7; -.
DR   OMA; IKPNYHK; -.
DR   OrthoDB; 896779at2759; -.
DR   Proteomes; UP000002036; Chromosome H.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018819; Nur1/Mug154.
DR   PANTHER; PTHR28293; PTHR28293; 1.
DR   Pfam; PF10332; DUF2418; 1.
PE   3: Inferred from homology;
KW   Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..592
FT                   /note="Nuclear rim protein 1"
FT                   /id="PRO_0000409030"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          547..592
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        557..583
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   592 AA;  67038 MW;  A46F47D3BEC9615E CRC64;
     MTFRLSRFES PLIEDDGESR ASLLGYSPEN ELYTDVDENR ESRFRRFMSF ISSSPYDMFL
     AINEHVESID WDSKASTIAG PLGNFFTCSL YTARLLQDSL IRPNQQKLDK KRDSFDLSRS
     EILRKFEYLS QVPKSGVVVT HLNWYWKFLT FLNVALQITV GFLILINLFV AYKFLIGHFQ
     VYSLFYTKTS PRSKNVTKRS LSDLSFKSLE EVTNSSLWTM IRYMFVRKRL IIKDAPKGKY
     YYQLRKWTPG KFYTALFSAF SPISVIFLLV TEVSFKTALA VIGHQYILFL VLFKRYESRL
     DDEACLAKAH FEEINEKVIK PKTTIKTQDA MVDATTYGGG AAFFPSFTTT RSHIFQTHAV
     TGDIITERYN PETRNFEDVE NTGRAKNYIS QIQGVSHGQQ VVSRSKAMNG ATARPQFFSR
     QPSPSKIGTP SIILNYRTSP FSAPTTPTLK PVNGVQNGQS IFRNSPDPSK ANSLNCDTSH
     LSRNNTLSRL RRNSVSPTKS GNYCSASGMR AIHKSNFGAD SSVSYSMEAP SNELPFEEVA
     RRGRHPFEIT ASRDLPAGRS SAVSSRHSSI SPFKGNTSFA GRESLDSRPP FR