ID   NUR1_ZYGRC              Reviewed;         511 AA.
AC   C5DQ18;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Nuclear rim protein 1;
GN   Name=NUR1; OrderedLocusNames=ZYRO0A07942g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Member of a perinuclear network that controls recombination
CC       at multiple loci to maintain genome stability. Required for rDNA repeat
CC       stability (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUR1 family. {ECO:0000305}.
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DR   EMBL; CU928173; CAR25779.1; -; Genomic_DNA.
DR   RefSeq; XP_002494712.1; XM_002494667.1.
DR   AlphaFoldDB; C5DQ18; -.
DR   STRING; 559307.C5DQ18; -.
DR   EnsemblFungi; CAR25779; CAR25779; ZYRO0A07942g.
DR   GeneID; 8201693; -.
DR   KEGG; zro:ZYRO0A07942g; -.
DR   HOGENOM; CLU_033252_0_0_1; -.
DR   InParanoid; C5DQ18; -.
DR   Proteomes; UP000008536; Chromosome A.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018819; Nur1/Mug154.
DR   PANTHER; PTHR28293; PTHR28293; 1.
DR   Pfam; PF10332; DUF2418; 1.
PE   3: Inferred from homology;
KW   Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..511
FT                   /note="Nuclear rim protein 1"
FT                   /id="PRO_0000409036"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          420..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        435..451
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        481..496
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        497..511
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   511 AA;  58897 MW;  8B666BFAD580A8D8 CRC64;
     MSLRISKDVS VSVNTADLLP EDDGFDRVDG DNRGWFSVFL GLFNTHPSDW NIALNEAIET
     IDWDSKSITL AQPLGNFFTF AFYVVRLLQL SLIKPNLSRI NEKTDHFDLS KSEMLKKYEY
     LYHFTNDKNQ SVGNVYYRFL GRLGKFFDIC IVLLTFTNGF ITYKFFWGNF KMYCLFYLKK
     GPHLRNVTKA SLQKLGQDDD DGSLWSSLRY FWNGTKDKEG STDDRDDDDG DIHYKLFKWT
     PSQFITMLFV SFAPTAVVFL LFTEVSFLTL IAVIVHQWVL HRLVIDCYGN RLVHESVIAS
     ANLAEVEAKF VKPRMSKKVQ DVAIDCTPHG DGMVKFYPAL TTNRSHIFQT HSLTGELITE
     TFNPSTKEFE DLQTEGTTHN VIRTAPYAAG DLLHRDPYWY QRNMIMRDVA HRPYFHSREV
     SPTRYHPSRI SPRPGQYSPL VSSTSGMSTP LMRPDRSPFL NTRPSLGERE ELFHRGNSRS
     PLRQPIENFK SLDRSSDSQS PIRRHNGDSD A