ID   ARP6_CHICK              Reviewed;         396 AA.
AC   Q9DEE9;
DT   27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Actin-related protein 6;
DE            Short=gArp6;
DE   AltName: Full=gARPX;
GN   Name=ACTR6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   TISSUE=Gonad;
RX   PubMed=11368909; DOI=10.1016/s0378-1119(01)00420-6;
RA   Kato M., Sasaki M., Mizuno S., Harata M.;
RT   "Novel actin-related proteins in vertebrates: similarities of structure and
RT   expression pattern to Arp6 localized on Drosophila heterochromatin.";
RL   Gene 268:133-140(2001).
RN   [2]
RP   SUBCELLULAR LOCATION, AND INTERACTION WITH CBX1 AND CBX3.
RX   PubMed=16487625; DOI=10.1016/j.ejcb.2005.12.006;
RA   Ohfuchi E., Kato M., Sasaki M., Sugimoto K., Oma Y., Harata M.;
RT   "Vertebrate Arp6, a novel nuclear actin-related protein, interacts with
RT   heterochromatin protein 1.";
RL   Eur. J. Cell Biol. 85:411-421(2006).
RN   [3]
RP   FUNCTION.
RX   PubMed=26164235; DOI=10.1016/j.bbrc.2015.07.005;
RA   Kitamura H., Matsumori H., Kalendova A., Hozak P., Goldberg I.G., Nakao M.,
RA   Saitoh N., Harata M.;
RT   "The actin family protein ARP6 contributes to the structure and the
RT   function of the nucleolus.";
RL   Biochem. Biophys. Res. Commun. 464:554-560(2015).
CC   -!- FUNCTION: Required for formation and/or maintenance of the proper
CC       nucleolar structure and function (By similarity). Plays a dual role in
CC       the regulation of ribosomal DNA (rDNA) transcription (PubMed:26164235).
CC       In the presence of high glucose, it maintains active rDNA transcription
CC       through H2A.Z deposition and under glucose starvation, is required for
CC       the repression of rDNA transcription, and this function may be
CC       independent of H2A.Z (PubMed:26164235). {ECO:0000250|UniProtKB:Q9GZN1,
CC       ECO:0000269|PubMed:26164235}.
CC   -!- SUBUNIT: Interacts with CBX1 and CBX3. {ECO:0000269|PubMed:16487625}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:P45890}. Nucleus {ECO:0000269|PubMed:16487625}.
CC       Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9GZN1}. Note=Colocalizes
CC       with HP1 family proteins at pericentric heterochromatin.
CC       {ECO:0000269|PubMed:16487625}.
CC   -!- DEVELOPMENTAL STAGE: Expressed abundantly in the early developmental
CC       stages. {ECO:0000269|PubMed:11368909}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP6 subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB038230; BAB20763.1; -; mRNA.
DR   RefSeq; NP_989968.1; NM_204637.1.
DR   AlphaFoldDB; Q9DEE9; -.
DR   SMR; Q9DEE9; -.
DR   STRING; 9031.ENSGALP00000018828; -.
DR   PaxDb; Q9DEE9; -.
DR   Ensembl; ENSGALT00000064051; ENSGALP00000045330; ENSGALG00000040976.
DR   GeneID; 395348; -.
DR   KEGG; gga:395348; -.
DR   CTD; 64431; -.
DR   VEuPathDB; HostDB:geneid_395348; -.
DR   eggNOG; KOG0680; Eukaryota.
DR   GeneTree; ENSGT00720000108833; -.
DR   InParanoid; Q9DEE9; -.
DR   OMA; FFEEYEC; -.
DR   OrthoDB; 649708at2759; -.
DR   PhylomeDB; Q9DEE9; -.
DR   TreeFam; TF105780; -.
DR   PRO; PR:Q9DEE9; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000040976; Expressed in spermatid and 14 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:AgBase.
DR   GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR   GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR   GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR   GO; GO:0016479; P:negative regulation of transcription by RNA polymerase I; IMP:UniProtKB.
DR   GO; GO:0007000; P:nucleolus organization; ISS:UniProtKB.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IMP:UniProtKB.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR030054; Arp6.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF47; PTHR11937:SF47; 1.
DR   Pfam; PF00022; Actin; 1.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   1: Evidence at protein level;
KW   Activator; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..396
FT                   /note="Actin-related protein 6"
FT                   /id="PRO_0000089107"
SQ   SEQUENCE   396 AA;  45784 MW;  E59B800F572D4EE3 CRC64;
     MATLVLDNGA YNAKIGYSHA HVSVIPNCQF RSKTARLKTF TANQLDEIKD PSGLFYILPF
     QKGYLVNWDV QRQVWDYLFG KEMYQVDFVD TNIIITEPYF NFSSIQESMN EILFEEYQFQ
     AVLRVNAGAL SAHRYFRDNP SELCCIIVDS GYSFTHIVPY CRSKKKKEAI IRINVGGKLL
     TNHLKEIISY RQLHVMDETH VINQVKEDVC YVSQDFYKDM EIAKLKGEEN TVMVDYVLPD
     FSTIKKGFCK PREEMVLSGK YKTGEQILRL TNERFAVPEI LFHPSDIGIQ EMGIPEAIVD
     SIQNLPEEMQ PHFFKNIVLT GGNTLFPGFR DRVYSEVRCL TPTDYDVSVV LPENPITYSW
     EGGKLISEND DFEDLVVTRE DYEEHGHNIC EEKFDI