ID   NURA_METJA              Reviewed;         389 AA.
AC   Q58658;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Probable DNA double-strand break repair nuclease NurA {ECO:0000250|UniProtKB:Q8U1N8};
DE            EC=3.1.-.- {ECO:0000250|UniProtKB:Q8U1N8};
GN   Name=nurA {ECO:0000250|UniProtKB:Q8U1N8};
GN   OrderedLocusNames=MJ1262 {ECO:0000312|EMBL:AAB99265.1};
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Involved in DNA double-strand break (DSB) repair (By
CC       similarity). Acts probably with HerA to stimulate resection of the 5'
CC       strand and produce the long 3' single-strand that is required for RadA
CC       loading (By similarity). {ECO:0000250|UniProtKB:Q8U1N8}.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000250|UniProtKB:Q8U1N8};
CC   -!- SIMILARITY: Belongs to the NurA family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99265.1; -; Genomic_DNA.
DR   PIR; E64457; E64457.
DR   AlphaFoldDB; Q58658; -.
DR   SMR; Q58658; -.
DR   STRING; 243232.MJ_1262; -.
DR   EnsemblBacteria; AAB99265; AAB99265; MJ_1262.
DR   KEGG; mja:MJ_1262; -.
DR   eggNOG; arCOG00367; Archaea.
DR   HOGENOM; CLU_056881_0_0_2; -.
DR   InParanoid; Q58658; -.
DR   OMA; YILKKSH; -.
DR   PhylomeDB; Q58658; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR018977; NurA_domain.
DR   Pfam; PF09376; NurA; 1.
DR   SMART; SM00933; NurA; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Hydrolase; Manganese; Metal-binding; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..389
FT                   /note="Probable DNA double-strand break repair nuclease
FT                   NurA"
FT                   /id="PRO_0000107244"
FT   BINDING         74
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250|UniProtKB:Q8U1N8"
FT   BINDING         151
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250|UniProtKB:Q8U1N8"
SQ   SEQUENCE   389 AA;  45314 MW;  28DBE8BEB9476404 CRC64;
     MFFKIFVENT VILPNPLILT KIEGLLMIEY LLKNREQIIK KMEKINDINR KEVEEKWILD
     NFENPKDMGF AGGDGSCNKL DYISFSFYGV GAVSFIHGRG EKVKKAKEEY IFDITHPLDI
     EDRIRRYMLT LELKTALYVL KNYNIDYYIF DGSLFSLLIF TKKGIEMYER ELEEIYNEYG
     KEFNKKIDEE TKSGEIGIIS KDLNLELNKK ILVEHVEYIL TLTKLINEFK DRIIGISKTS
     KINIYFDKNM PDIAIFTKYT DKSGYSEPID FVNKLGDEKK EKHKQLSSVV KGINFIKNKP
     FYAKIDTAYI QFVRLEDNCG VVGLTSFNKI DKEVLSSLKE ISINGYPYIL KKSHETVEIT
     TKKLEAIAKL LNIDDPIARH ILGKKKKKF