ID   NUSAP_CHICK             Reviewed;         466 AA.
AC   Q5ZJU5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Nucleolar and spindle-associated protein 1;
DE            Short=NuSAP;
GN   Name=NUSAP1; ORFNames=RCJMB04_15k16;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Microtubule-associated protein with the capacity to bundle
CC       and stabilize microtubules. May associate with chromosomes and promote
CC       the organization of mitotic spindle microtubules around them (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with DNA and microtubules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Associates with
CC       mitotic spindle microtubules, particularly in the vicinity of
CC       chromosomes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUSAP family. {ECO:0000305}.
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DR   EMBL; AJ720339; CAG31998.1; -; mRNA.
DR   RefSeq; NP_001026364.1; NM_001031193.1.
DR   AlphaFoldDB; Q5ZJU5; -.
DR   STRING; 9031.ENSGALP00000013962; -.
DR   PaxDb; Q5ZJU5; -.
DR   GeneID; 423213; -.
DR   KEGG; gga:423213; -.
DR   CTD; 51203; -.
DR   VEuPathDB; HostDB:geneid_423213; -.
DR   eggNOG; ENOG502QVI7; Eukaryota.
DR   InParanoid; Q5ZJU5; -.
DR   OrthoDB; 1573441at2759; -.
DR   PhylomeDB; Q5ZJU5; -.
DR   PRO; PR:Q5ZJU5; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0040001; P:establishment of mitotic spindle localization; IBA:GO_Central.
DR   GO; GO:0007076; P:mitotic chromosome condensation; IBA:GO_Central.
DR   GO; GO:0000281; P:mitotic cytokinesis; IBA:GO_Central.
DR   InterPro; IPR026756; NuSAP.
DR   PANTHER; PTHR15874; PTHR15874; 1.
DR   Pfam; PF16006; NUSAP; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; DNA-binding;
KW   Microtubule; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..466
FT                   /note="Nucleolar and spindle-associated protein 1"
FT                   /id="PRO_0000302036"
FT   REGION          47..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          239..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          338..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          395..466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..141
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..161
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..358
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..453
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   466 AA;  52267 MW;  B3CD140213D3B186 CRC64;
     MALSSQLQSL DALKYVELQQ VAKAAGLRAN LRADKLLKAL KQHFQGRIQE NENTSSEKSA
     SSSMDSELSC QQEFMPNPAC FVTKRCKEKK ATRKKKSSDM ETNDSEENTG PSAEIEGHSE
     TKENEVPQGD CEKEKMVFQN VEQVTKKRAN ENPSMATAEK KQPKRTSTKS ARAKCDPHPV
     GQKIPLHVGS ASKPGKTGLK ATTPNFKRLH EAHFKKMESI ADYIERKKKM LENCSSSLNE
     AKRHTSSKTL LFSPNPDRGR FSGTCTPSNL RRSPRGLLNT GSQSILSRKS SFNPSVLSTT
     KMNVRFSEAT KDNEHKRSLT KTPSRMSPYV EEICTPDSQK SCEPLSAKNS KRSTRNNDLP
     ALKAITPFKF AAQSAEPSST KKVFDLKASL SRPLRYQPHK GRLKPWGELK ENAPLKKSVS
     NSITSHKRDY KQPHLQSRED RREKHEQERK KKKAQALGNR RGLSMG