ID   ARP6_CRYNB              Reviewed;         490 AA.
AC   P0CM05; Q55KS0; Q5KAQ4;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Actin-like protein ARP6;
GN   Name=ARP6; OrderedLocusNames=CNBJ2630;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Involved in chromosome stability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP6 subfamily. {ECO:0000305}.
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DR   EMBL; AAEY01000050; EAL18340.1; -; Genomic_DNA.
DR   RefSeq; XP_772987.1; XM_767894.1.
DR   AlphaFoldDB; P0CM05; -.
DR   SMR; P0CM05; -.
DR   EnsemblFungi; AAW45951; AAW45951; CNJ00880.
DR   EnsemblFungi; EAL18340; EAL18340; CNBJ2630.
DR   GeneID; 4938606; -.
DR   KEGG; cnb:CNBJ2630; -.
DR   VEuPathDB; FungiDB:CNBJ2630; -.
DR   HOGENOM; CLU_027965_1_1_1; -.
DR   Proteomes; UP000001435; Chromosome 10.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0000812; C:Swr1 complex; IEA:EnsemblFungi.
DR   GO; GO:0006338; P:chromatin remodeling; IEA:EnsemblFungi.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR030054; Arp6.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF47; PTHR11937:SF47; 1.
DR   Pfam; PF00022; Actin; 1.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Cytoplasm; Cytoskeleton; Nucleus;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..490
FT                   /note="Actin-like protein ARP6"
FT                   /id="PRO_0000410003"
FT   REGION          260..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          456..490
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..477
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   490 AA;  55010 MW;  9A072AE55006B1C0 CRC64;
     MATPPVLIID NGAYEIKAGI SGVDWEPRVL PNSIARSRTE KRVYVGDEID NCKDLSGIVY
     RRPFEKGMLV NWDAERIIWD RLFSPSVLNI NPTETSLLVT EPYFNLPNIA ETYDQMIFEE
     FEFQSYFRCA PAALIPYGGL YESDQGIPPQ CTIVIDMGYS YTHVVPIRDG QIVWEHVKRI
     DVGGKLLTNH LKHLISFRQW NMIDQTHVVN SVREACGYVS LNWKGDLETC KAKPRKNPII
     QEYVLPDFSA NSTSRTGYIR SGPNAAPPEE TNGTGEVNGK QKPEEEEQVL WMGNERFAGP
     ELLFHPSDIG LKQTGLPETI AYVISQMPEE LRGMFWAHIG IIGGLGNIEN LGERLERDLQ
     ALCPVEYEIG IYEAFDPASL AYTSATALTS SEVYMSTYPV TRTEYFEQGS SLCRRKFGSF
     GAPAYNIDPP GFSSGVDART EVSDDEMEMR YAMGLESKKG GKGKRRKEEE EVTSGNWGGR
     RRRTTGLGGF