ID   NUSA_RICPR              Reviewed;         503 AA.
AC   Q9ZCZ7;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Transcription termination/antitermination protein NusA {ECO:0000255|HAMAP-Rule:MF_00945};
GN   Name=nusA {ECO:0000255|HAMAP-Rule:MF_00945}; OrderedLocusNames=RP553;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: Participates in both transcription termination and
CC       antitermination. {ECO:0000255|HAMAP-Rule:MF_00945}.
CC   -!- SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-
CC       dependent RNA polymerase and to nascent RNA. {ECO:0000255|HAMAP-
CC       Rule:MF_00945}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00945}.
CC   -!- SIMILARITY: Belongs to the NusA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00945}.
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DR   EMBL; AJ235272; CAA15002.1; -; Genomic_DNA.
DR   PIR; H71659; H71659.
DR   RefSeq; NP_220925.1; NC_000963.1.
DR   RefSeq; WP_004597846.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZCZ7; -.
DR   SMR; Q9ZCZ7; -.
DR   STRING; 272947.RP553; -.
DR   PRIDE; Q9ZCZ7; -.
DR   EnsemblBacteria; CAA15002; CAA15002; CAA15002.
DR   GeneID; 57569676; -.
DR   KEGG; rpr:RP553; -.
DR   PATRIC; fig|272947.5.peg.566; -.
DR   eggNOG; COG0195; Bacteria.
DR   eggNOG; COG0272; Bacteria.
DR   HOGENOM; CLU_029242_0_0_5; -.
DR   OMA; MDIDMSA; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.30.1480.10; -; 1.
DR   Gene3D; 3.30.300.20; -; 2.
DR   HAMAP; MF_00945_B; NusA_B; 1.
DR   InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR025249; KH_dom_NusA-like.
DR   InterPro; IPR009019; KH_sf_prok-type.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR030842; NusA_bac.
DR   InterPro; IPR036555; NusA_N_sf.
DR   InterPro; IPR022967; S1_dom.
DR   InterPro; IPR003029; S1_domain.
DR   InterPro; IPR013735; TF_NusA_N.
DR   InterPro; IPR010214; Tscrpt_termin_fac_NusA_C_rpt.
DR   InterPro; IPR010213; Tscrpt_termination_fac_NusA.
DR   PANTHER; PTHR22648; PTHR22648; 1.
DR   Pfam; PF13184; KH_5; 1.
DR   Pfam; PF08529; NusA_N; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00322; KH; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF47794; SSF47794; 2.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF54814; SSF54814; 2.
DR   SUPFAM; SSF69705; SSF69705; 1.
DR   TIGRFAMs; TIGR01953; NusA; 1.
DR   TIGRFAMs; TIGR01954; nusA_Cterm_rpt; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
DR   PROSITE; PS50126; S1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; RNA-binding; Transcription;
KW   Transcription antitermination; Transcription regulation;
KW   Transcription termination.
FT   CHAIN           1..503
FT                   /note="Transcription termination/antitermination protein
FT                   NusA"
FT                   /id="PRO_0000181977"
FT   DOMAIN          139..203
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00945"
FT   DOMAIN          308..378
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00945"
SQ   SEQUENCE   503 AA;  56883 MW;  56ADB03ADA1F88A6 CRC64;
     MSNIYNIEIL QIIDSVAREK GISKEILIST VEQAVQVAGR KKYGNEYNIK AQINRKTGEI
     NLLRILKIVE DVEDYLTQIS LEDALVKNPE AKIGDEIYEY LPPIDHARVS AQAAKQVITQ
     RVIEAEREKQ YHDFKDRKGD IINGIVKRIE YGDIIVDLSR AEAIIKKDQL IKGEHFKPND
     RIKAYVQDVR QETKGPQIFL SRVDNQMLVK LFKLEVPEIL EDIIQIKSVA RDPGSKAKIA
     VFASDSSIDP VGSCVGIRGN RVKAVTNELN GEKIDIVLWS NDLAQFIVNS LIPLAPSEIT
     KILIDEDSHK VEVVVSQEHQ SIAIGRRGQN VRLASKLTGW NIDIMTEEQE SKRRNEEFST
     STELFMEALD VEEVIGQLLS VTGFNSVEQI ASSEISTLTR IEGFEEELAV EIKNRAIHYV
     DLKNEKIIKK LEELGVEQEL IDILELPLEL ILKFAEYGIK TIEDLGEMSV NEFKNLAPNS
     NITDENIKLL IKTARHHGEL KDS