ARP6_DROME
ID ARP6_DROME Reviewed; 398 AA.
AC P45890; Q9VXQ9;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Actin-related protein 6;
DE Short=dArp6;
DE AltName: Full=Actin-like protein 13E;
GN Name=Arp6; Synonyms=Acrp, Actr13E, Arp4; ORFNames=CG11678;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=Canton-S;
RX PubMed=8308899; DOI=10.1006/jmbi.1994.1090;
RA Frankel S., Heintzelman M.B., Artavanis-Tsakonas S., Mooseker M.S.;
RT "Identification of a divergent actin-related protein in Drosophila.";
RL J. Mol. Biol. 235:1351-1356(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=9378752; DOI=10.1242/jcs.110.17.1999;
RA Frankel S., Sigel E.A., Craig C., Elgin S.C., Mooseker M.S.,
RA Artavanis-Tsakonas S.;
RT "An actin-related protein in Drosophila colocalizes with heterochromatin
RT protein 1 in pericentric heterochromatin.";
RL J. Cell Sci. 110:1999-2012(1997).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000269|PubMed:9378752}. Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:9378752}. Note=Colocalizes with Su(var)205/HP1 on
CC centric heterochromatin.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Expressed throughout development, with highest expression observed in
CC embryos (at protein level). {ECO:0000269|PubMed:8308899,
CC ECO:0000269|PubMed:9378752}.
CC -!- SIMILARITY: Belongs to the actin family. ARP6 subfamily. {ECO:0000305}.
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DR EMBL; L25314; AAA17685.1; -; mRNA.
DR EMBL; AE014298; AAF48499.1; -; Genomic_DNA.
DR EMBL; AY058726; AAL13955.1; -; mRNA.
DR PIR; S44028; S44028.
DR RefSeq; NP_511165.1; NM_078610.3.
DR AlphaFoldDB; P45890; -.
DR SMR; P45890; -.
DR BioGRID; 58864; 23.
DR DIP; DIP-17460N; -.
DR IntAct; P45890; 4.
DR STRING; 7227.FBpp0073983; -.
DR PaxDb; P45890; -.
DR PRIDE; P45890; -.
DR DNASU; 32514; -.
DR EnsemblMetazoa; FBtr0074203; FBpp0073983; FBgn0011741.
DR GeneID; 32514; -.
DR KEGG; dme:Dmel_CG11678; -.
DR CTD; 32514; -.
DR FlyBase; FBgn0011741; Arp6.
DR VEuPathDB; VectorBase:FBgn0011741; -.
DR eggNOG; KOG0680; Eukaryota.
DR GeneTree; ENSGT00720000108833; -.
DR HOGENOM; CLU_027965_1_1_1; -.
DR InParanoid; P45890; -.
DR OMA; FFEEYEC; -.
DR OrthoDB; 649708at2759; -.
DR PhylomeDB; P45890; -.
DR SignaLink; P45890; -.
DR BioGRID-ORCS; 32514; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 32514; -.
DR PRO; PR:P45890; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0011741; Expressed in eye disc (Drosophila) and 24 other tissues.
DR Genevisible; P45890; DM.
DR GO; GO:0000785; C:chromatin; IDA:FlyBase.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; ISS:FlyBase.
DR GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR GO; GO:0070828; P:heterochromatin organization; ISS:FlyBase.
DR GO; GO:0043486; P:histone exchange; IMP:FlyBase.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR030054; Arp6.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR PANTHER; PTHR11937:SF47; PTHR11937:SF47; 1.
DR Pfam; PF00022; Actin; 1.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT CHAIN 1..398
FT /note="Actin-related protein 6"
FT /id="PRO_0000089108"
SQ SEQUENCE 398 AA; 45415 MW; 71905627B3F0FC05 CRC64;
MANAVVVLDN GAHTAKVGLA NQDEPHVVPN CIMKAKSERR RAFVGNQIDE CRDTSALYYI
LAFQRGYLLN WHTQKTVWDY IFSKDGIGCS LENRNIVITE PQMNFQSIQE ATLEILFEEY
KVDGVYKTTA ADLAAFNYVA DSEERTTMES LNCIIIDVGY SFTHVVPFVL GRRVLQGIRR
IDMGGKALTN QLKELISYRH LNVMDESHVV NQIKEDVCFV AEDFKQAMQV HYSEEKRREV
TVDYVLPDFT TVKRGYVRVP GKPREDEEQQ QMVSLCNERF TVPELLFNPS DIGVQQVGIP
EAVADCLKAC PWEAHRELLL NILIVGGSAQ FPGFLPRLKR DLRALVPDDL EVSLICPEDP
VRYAWYGGKE VATSPNFEEF VYTQDDYEEY GFQGINQR
