ID   ARP6_KLULA              Reviewed;         415 AA.
AC   Q6CJF4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Actin-like protein ARP6;
GN   Name=ARP6; OrderedLocusNames=KLLA0F19063g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Involved in chromosome stability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP6 subfamily. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98643.1; -; Genomic_DNA.
DR   RefSeq; XP_455935.1; XM_455935.1.
DR   AlphaFoldDB; Q6CJF4; -.
DR   SMR; Q6CJF4; -.
DR   STRING; 28985.XP_455935.1; -.
DR   EnsemblFungi; CAG98643; CAG98643; KLLA0_F19063g.
DR   GeneID; 2895554; -.
DR   KEGG; kla:KLLA0_F19063g; -.
DR   eggNOG; KOG0680; Eukaryota.
DR   HOGENOM; CLU_027965_1_1_1; -.
DR   InParanoid; Q6CJF4; -.
DR   OMA; FFEEYEC; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR   GO; GO:0000812; C:Swr1 complex; IEA:EnsemblFungi.
DR   GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR   GO; GO:0043486; P:histone exchange; IEA:EnsemblFungi.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR030054; Arp6.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF47; PTHR11937:SF47; 1.
DR   Pfam; PF00022; Actin; 1.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Cytoplasm; Cytoskeleton; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..415
FT                   /note="Actin-like protein ARP6"
FT                   /id="PRO_0000089117"
SQ   SEQUENCE   415 AA;  48428 MW;  D7E83CAAFF6A9FEC CRC64;
     MSEPVLVIDN GSYEIKFGES GWDQPLRALN CLTKDKYSRF HLSNQTKKMR DISQALIRRP
     HELGQLVSWE LESEVWDYCF YNEDDFHWNL THDNDTKDHH LVVSETLMTI PELSKNMDQV
     IFEEYDFKSM FKGPVAQYIP FYQGQYQDDA MTAAEDKKTS SYKDFQLVID SGFNCTWAVP
     IIKGVPYYKA IKKLDIGGRF LTGLLQETIS FRHYNVMEET ILVNNIKEQC TFVPPESYFS
     SFHNKMNTKV EYVLPDFQTS FLGYVKKPGK EKLTDDAQTL LLTDEVFSVP ETFFHPEIAQ
     ILKPGIVETI LECINMCPEV VRPLLVANIV CTGGNFNIPN FHERLQTELQ RQCPIDWSCK
     VHSPQEKDKS LHGWESMKDF ANSDQFRSAR VTREEYLEHG LDWCTKNRFG YQQWL