ID   ARP6_NEUCR              Reviewed;         446 AA.
AC   Q7S6X6; V5IKN4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Actin-related protein 6;
GN   Name=arp-6; ORFNames=NCU05587;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant H2A.Z leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Involved in chromosome stability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP6 subfamily. {ECO:0000305}.
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DR   EMBL; CM002241; ESA42173.1; -; Genomic_DNA.
DR   EMBL; CM002241; ESA42174.1; -; Genomic_DNA.
DR   RefSeq; XP_011394970.1; XM_011396668.1.
DR   RefSeq; XP_011394971.1; XM_011396669.1.
DR   AlphaFoldDB; Q7S6X6; -.
DR   SMR; Q7S6X6; -.
DR   STRING; 5141.EFNCRP00000005656; -.
DR   EnsemblFungi; ESA42173; ESA42173; NCU05587.
DR   EnsemblFungi; ESA42174; ESA42174; NCU05587.
DR   GeneID; 3876711; -.
DR   KEGG; ncr:NCU05587; -.
DR   VEuPathDB; FungiDB:NCU05587; -.
DR   HOGENOM; CLU_027965_1_1_1; -.
DR   InParanoid; Q7S6X6; -.
DR   OMA; FFEEYEC; -.
DR   Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR   GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR   GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR030054; Arp6.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF47; PTHR11937:SF47; 1.
DR   Pfam; PF00022; Actin; 1.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Cytoplasm; Cytoskeleton; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..446
FT                   /note="Actin-related protein 6"
FT                   /id="PRO_0000089118"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   446 AA;  49886 MW;  04F6DB1403DB7C7B CRC64;
     MTGRGGAKKS RAAGPAPPTT TLVLDNGADT IKAGFVSDDK SDGKPRIIPN CLARDRHRKI
     YVGSELEKCK DFSELAFRRP VEKGFIVNWE AQKEIWDREF FDDKAAQKCD PSDTRLILTE
     QPNSLPSLQT HCDQIVFEEY GFASYYRGLG PVFNAYRDIQ SIFRTPQSTI DSPAQVILLI
     DSGYSHTTVT PILQGRPLHP AIRRLDVGGK LMTNYLTRLL SVRHFDMRNE PYIVNEMKEA
     VCYTSLDFKG DLEKTWKGTR GEKREDYLSG AGIAKDYVLP DSHTRFHGVV RDYEPGVSAR
     ARKGIVSTED VLTLRNERFV VPELLFNPSD IGIRQPGIAD LVKQSLLAVP IGLWPGLLAN
     IVVVGGNSLS EGFCQRLQTE ILKRFPDECR VRVARPEDPI ISTWLGAANF AKHEHASKLE
     VTKQEYEEHG AAWVARKFAA GLGLDP