ID   ARP6_SCHPO              Reviewed;         401 AA.
AC   O94241;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Actin-like protein arp6;
GN   Name=arp6; ORFNames=SPCC550.12;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Involved in chromosome stability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP6 subfamily. {ECO:0000305}.
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DR   EMBL; CU329672; CAA19116.1; -; Genomic_DNA.
DR   PIR; T41387; T41387.
DR   RefSeq; NP_588104.1; NM_001023095.2.
DR   AlphaFoldDB; O94241; -.
DR   SMR; O94241; -.
DR   BioGRID; 276125; 115.
DR   STRING; 4896.SPCC550.12.1; -.
DR   MaxQB; O94241; -.
DR   PaxDb; O94241; -.
DR   EnsemblFungi; SPCC550.12.1; SPCC550.12.1:pep; SPCC550.12.
DR   GeneID; 2539564; -.
DR   KEGG; spo:SPCC550.12; -.
DR   PomBase; SPCC550.12; arp6.
DR   VEuPathDB; FungiDB:SPCC550.12; -.
DR   eggNOG; KOG0680; Eukaryota.
DR   HOGENOM; CLU_027965_1_1_1; -.
DR   InParanoid; O94241; -.
DR   OMA; FFEEYEC; -.
DR   PhylomeDB; O94241; -.
DR   PRO; PR:O94241; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0000812; C:Swr1 complex; IDA:PomBase.
DR   GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IPI:PomBase.
DR   GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR   GO; GO:0034728; P:nucleosome organization; IC:PomBase.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR030054; Arp6.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF47; PTHR11937:SF47; 1.
DR   Pfam; PF00022; Actin; 1.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Cytoplasm; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..401
FT                   /note="Actin-like protein arp6"
FT                   /id="PRO_0000089119"
SQ   SEQUENCE   401 AA;  45881 MW;  0369E7C2B36D1EB6 CRC64;
     MGLPPKTIVL DNGAYHIKAG FAGGKVVEIP NCLTRSKDGN RLFLGNELAN CNDFTTLQFR
     RAHEKGYLVH WSTETAVWDL VMRNVGVMEP SMADYSLLLT QPVFTMPSIE HNTIQLVFEE
     FQFDAYLPCT PAELIPWDHG SFTMNQEDAY TGQHGECVLV IDSGYSFTHI IPVIDFSVQE
     QAVKRVDVGG KLLTNYLKEV ISYRKYNMME ETYIVNEIKE SVCYVSQNFK EDMEICHEKP
     RSKLEICYAL PDYSTGKHGY IVRDINQKIE QQVLNLSNER FMIPELLFSP SDIEIREAGI
     PEAVMQSVTH FPENIQAMLL ENVVTIGGNC KFPGFHKRLS SELRSLAPAN WEVKVFEPSD
     PICFPWKKAS HMPLEHWNAN KITRSEYSEH GANIMTRKRR I