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ARP8_ARATH
ID   ARP8_ARATH              Reviewed;         471 AA.
AC   Q9FKT0; Q7PCC3; Q84WA6; Q8L8Z7; Q8LKQ9;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Actin-related protein 8;
DE   AltName: Full=F-box protein ARP8;
GN   Name=ARP8; OrderedLocusNames=At5g56180; ORFNames=MDA7.26;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), IDENTIFICATION, TISSUE
RP   SPECIFICITY, AND GENE FAMILY.
RC   STRAIN=cv. Columbia;
RX   PubMed=11891255; DOI=10.1104/pp.010906;
RA   McKinney E.C., Kandasamy M.K., Meagher R.B.;
RT   "Arabidopsis contains ancient classes of differentially expressed actin-
RT   related protein genes.";
RL   Plant Physiol. 128:997-1007(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA   Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT   features of the regions of 1,381,565 bp covered by twenty one physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:131-145(1998).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   REVIEW, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15063870; DOI=10.1016/j.tplants.2004.02.004;
RA   Kandasamy M.K., Deal R.B., McKinney E.C., Meagher R.B.;
RT   "Plant actin-related proteins.";
RL   Trends Plant Sci. 9:196-202(2004).
RN   [7]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=18385164; DOI=10.1093/pcp/pcn053;
RA   Kandasamy M.K., McKinney E.C., Meagher R.B.;
RT   "ACTIN-RELATED PROTEIN8 encodes an F-box protein localized to the nucleolus
RT   in Arabidopsis.";
RL   Plant Cell Physiol. 49:858-863(2008).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:18385164}.
CC       Cytoplasm {ECO:0000269|PubMed:18385164}. Note=Localized to the
CC       nucleolus in interphase cells and dispersed in the cytoplasm in mitotic
CC       cells.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1; Synonyms=ARP8B;
CC         IsoId=Q9FKT0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9FKT0-2; Sequence=VSP_022941, VSP_022942;
CC       Name=3;
CC         IsoId=Q9FKT0-3; Sequence=VSP_022939;
CC       Name=4; Synonyms=ARP8A;
CC         IsoId=Q9FKT0-4; Sequence=VSP_022940;
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed in all organs and cell
CC       types. Higher expression in seedlings. {ECO:0000269|PubMed:11891255,
CC       ECO:0000269|PubMed:18385164}.
CC   -!- SIMILARITY: Belongs to the actin family. Plant ARP8 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF507916; AAM53248.1; -; mRNA.
DR   EMBL; AF507917; AAM53249.1; -; mRNA.
DR   EMBL; AB011476; BAB09300.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED96730.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED96731.1; -; Genomic_DNA.
DR   EMBL; BT004068; AAO42095.1; -; mRNA.
DR   EMBL; AY088717; AAM67035.1; -; mRNA.
DR   EMBL; BK000426; DAA00031.1; -; Genomic_DNA.
DR   EMBL; BK000426; DAA00032.1; -; Genomic_DNA.
DR   RefSeq; NP_568836.2; NM_125000.4. [Q9FKT0-1]
DR   RefSeq; NP_974940.1; NM_203211.1. [Q9FKT0-2]
DR   AlphaFoldDB; Q9FKT0; -.
DR   SMR; Q9FKT0; -.
DR   STRING; 3702.AT5G56180.1; -.
DR   PaxDb; Q9FKT0; -.
DR   PRIDE; Q9FKT0; -.
DR   ProteomicsDB; 246891; -. [Q9FKT0-1]
DR   EnsemblPlants; AT5G56180.1; AT5G56180.1; AT5G56180. [Q9FKT0-1]
DR   EnsemblPlants; AT5G56180.2; AT5G56180.2; AT5G56180. [Q9FKT0-2]
DR   GeneID; 835717; -.
DR   Gramene; AT5G56180.1; AT5G56180.1; AT5G56180. [Q9FKT0-1]
DR   Gramene; AT5G56180.2; AT5G56180.2; AT5G56180. [Q9FKT0-2]
DR   KEGG; ath:AT5G56180; -.
DR   Araport; AT5G56180; -.
DR   TAIR; locus:2161795; AT5G56180.
DR   eggNOG; KOG0676; Eukaryota.
DR   HOGENOM; CLU_036757_0_0_1; -.
DR   InParanoid; Q9FKT0; -.
DR   OrthoDB; 572248at2759; -.
DR   PhylomeDB; Q9FKT0; -.
DR   PRO; PR:Q9FKT0; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FKT0; baseline and differential.
DR   Genevisible; Q9FKT0; AT.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005869; C:dynactin complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; ISS:TAIR.
DR   GO; GO:0030029; P:actin filament-based process; TAS:TAIR.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   SMART; SM00268; ACTIN; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ATP-binding; Cytoplasm; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..471
FT                   /note="Actin-related protein 8"
FT                   /id="PRO_0000274923"
FT   DOMAIN          40..86
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   BINDING         256..259
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         164..165
FT                   /note="EF -> VR (in isoform 3)"
FT                   /evidence="ECO:0000303|Ref.5"
FT                   /id="VSP_022939"
FT   VAR_SEQ         233..462
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:11891255"
FT                   /id="VSP_022940"
FT   VAR_SEQ         364..387
FT                   /note="MRAMSLHQAVSLCMDHCDAAGLTG -> IIVHKLVYEFHGFPYAYQGWAIFL
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14593172"
FT                   /id="VSP_022941"
FT   VAR_SEQ         388..471
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14593172"
FT                   /id="VSP_022942"
FT   CONFLICT        24
FT                   /note="Q -> H (in Ref. 1; AAM53249)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        260
FT                   /note="Q -> K (in Ref. 4; AAO42095)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   471 AA;  52510 MW;  6BA4ABAE3AB8DE6E CRC64;
     MILKKVWGSV WNRSNSGKDL VNHQRAIDVP PLLLSSSSSL GAFDQLPMDI LVQILMMMEP
     KDAVKLGLTC KAWKCVASGN RLWIFYLQCS QEPWDSIFFA ETSLRSGYPL RMISSQSGEL
     SFMHIYSQRA QVPGSIIIDG GSGYCKFGWS KYASPSGRSA TFLEFGNIES PIYARLQQFF
     ATIFTRMQVK PSMQPIVVSL PLCHFDDTES AKASRRQLKT AIFNVLFDMN VPAVCAVNQA
     VLALYAARRT SGIVVNIGFQ VITILPILHG KVMRQVGVEV IGFGALKLTG FLKEKMQENN
     ISFQSLYTVR TLKEKLCYVA LDYKAELSKD TQASVEVSGE GWFTLSKERF QTGEILFQPR
     LAGMRAMSLH QAVSLCMDHC DAAGLTGDDS WFKTVVLTGG SACLPGLSER LERELQDHLP
     SSISNGIRVI PPPYGVDTSW HGAKLISNLS IFPGPWCITR KQFRRKSRLM W
 
 
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