ID   ARP8_DROPS              Reviewed;         608 AA.
AC   Q29G73;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Actin-related protein 8;
GN   Name=Arp8 {ECO:0000250|UniProtKB:Q9VX09}; ORFNames=GA20628;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Plays an important role in the functional organization of
CC       mitotic chromosomes. Exhibits low basal ATPase activity, and unable to
CC       polymerize (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Proposed core component of the chromatin remodeling INO80
CC       complex which is involved in transcriptional regulation, DNA
CC       replication and probably DNA repair. Strongly prefer nucleosomes and
CC       H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a
CC       nucleosome recognition module within the complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the chromatin remodeling Ino80 complex. Exists as
CC       monomers and dimers, but the dimer is most probably the biologically
CC       relevant form required for stable interactions with histones that
CC       exploits the twofold symmetry of the nucleosome core (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VX09}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP8 subfamily. {ECO:0000305}.
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DR   EMBL; CH379064; EAL32237.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q29G73; -.
DR   SMR; Q29G73; -.
DR   STRING; 7237.FBpp0275624; -.
DR   eggNOG; KOG0797; Eukaryota.
DR   HOGENOM; CLU_006974_1_0_1; -.
DR   InParanoid; Q29G73; -.
DR   OMA; CFIQESL; -.
DR   Proteomes; UP000001819; Genome assembly.
DR   GO; GO:0031011; C:Ino80 complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006338; P:chromatin remodeling; ISS:UniProtKB.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR027668; Arp8/plant_Arp9.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF13; PTHR11937:SF13; 1.
DR   Pfam; PF00022; Actin; 2.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA recombination; DNA repair; Nucleotide-binding;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..608
FT                   /note="Actin-related protein 8"
FT                   /id="PRO_0000307120"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         272..275
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   608 AA;  68556 MW;  E021F436202DB540 CRC64;
     MQRSRASSTS SGRLQASQQV QPLDAPKIIV IHPGSQHLRI GRACDLNPLT MLHAVAYKRK
     HQEGDWPYHD PMLPSLDNIN PAQLQVEFEE QRLIASRILQ NCVIDDKQRL RVATPPQQLA
     HFNRKSVAEK IPPPGNLSEE RNRQWLDRDA PVLFDEQILR LSTFDARDYD IHFPIQRGEL
     NVHKQKGGSL QCTLQHIERI WSYALEARLK INLRDLRTHS AVLVVNDVYV RRHLREFMTL
     LLQRLGFQRC FLVQDSVAST YGAGIGFGCV VDIGAQKTSI ACIEDGISQL NSRVRLQYGG
     GDINQVLLML LRKCGFPYRE CSVQDSYVDA RLMDKLKERF CHLNAKVCGA QEKQFHLRKQ
     NGQWLRYTLQ VGDEAIMAPL AFFHTELLNI TGKARKAFTQ QPPQEQYDCE DCFDAEYLRE
     TGRKNGARAA DPIVAQLLAQ PRPLPPITAD DEELNVVDQD EPSSNGVAVH NTSSPSVGHA
     QKHFADTANG VYQYGQGQVM PLDQAVLEAI GRCATNETKR KMYGSILLVG SSVKIPGLAA
     WLQSCISQQV QPGTEVNVFT KGMDAGMVAW KGAAIMSVLE SARELWITQV DWSRHGLRLL
     RERSPFLW