ID   NUSB_MYCLE              Reviewed;         190 AA.
AC   Q9CCR9;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Transcription antitermination protein NusB {ECO:0000255|HAMAP-Rule:MF_00073};
DE   AltName: Full=Antitermination factor NusB {ECO:0000255|HAMAP-Rule:MF_00073};
GN   Name=nusB {ECO:0000255|HAMAP-Rule:MF_00073}; OrderedLocusNames=ML0523;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Involved in transcription antitermination. Required for
CC       transcription of ribosomal RNA (rRNA) genes. Binds specifically to the
CC       boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
CC       {ECO:0000255|HAMAP-Rule:MF_00073}.
CC   -!- SIMILARITY: Belongs to the NusB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00073, ECO:0000305}.
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DR   EMBL; AL583918; CAC30031.1; -; Genomic_DNA.
DR   PIR; C86974; C86974.
DR   RefSeq; NP_301448.1; NC_002677.1.
DR   RefSeq; WP_010907772.1; NC_002677.1.
DR   AlphaFoldDB; Q9CCR9; -.
DR   SMR; Q9CCR9; -.
DR   STRING; 272631.ML0523; -.
DR   EnsemblBacteria; CAC30031; CAC30031; CAC30031.
DR   KEGG; mle:ML0523; -.
DR   PATRIC; fig|272631.5.peg.912; -.
DR   Leproma; ML0523; -.
DR   eggNOG; COG0781; Bacteria.
DR   HOGENOM; CLU_087843_2_0_11; -.
DR   OMA; DRMPVVD; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.940.10; -; 1.
DR   HAMAP; MF_00073; NusB; 1.
DR   InterPro; IPR035926; NusB-like_sf.
DR   InterPro; IPR011605; NusB_fam.
DR   InterPro; IPR006027; NusB_RsmB_TIM44.
DR   PANTHER; PTHR11078; PTHR11078; 1.
DR   Pfam; PF01029; NusB; 1.
DR   SUPFAM; SSF48013; SSF48013; 1.
DR   TIGRFAMs; TIGR01951; nusB; 1.
PE   3: Inferred from homology;
KW   Reference proteome; RNA-binding; Transcription;
KW   Transcription antitermination; Transcription regulation.
FT   CHAIN           1..190
FT                   /note="Transcription antitermination protein NusB"
FT                   /id="PRO_0000176556"
FT   REGION          158..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   190 AA;  20519 MW;  5D870FC8DA1C3B62 CRC64;
     MSNPVKGRHQ ARKRAVDLLF EAEARDLSPL EIIEVRSALA KSKLDVAPLH PYTVVVAQGV
     SEHTARIDEL IISHLQGWKL DRLPAVDRAI LRVSIWELLY ADDVPEPVAV DEAVELAKEL
     STDDSPGFVN GLLGKVMLVT PQIRAAAQAV QQAVRMAAGT SEDHVPQREP AAGQLGQDDS
     NGGQVAAVCR