ID   NUSB_MYCTO              Reviewed;         156 AA.
AC   P9WIV0; L0TCN2; P95020;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Transcription antitermination protein NusB {ECO:0000255|HAMAP-Rule:MF_00073};
DE   AltName: Full=Antitermination factor NusB {ECO:0000255|HAMAP-Rule:MF_00073};
GN   Name=nusB {ECO:0000255|HAMAP-Rule:MF_00073}; OrderedLocusNames=MT2608;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Involved in transcription antitermination. Required for
CC       transcription of ribosomal RNA (rRNA) genes. Binds specifically to the
CC       boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
CC       {ECO:0000255|HAMAP-Rule:MF_00073}.
CC   -!- SIMILARITY: Belongs to the NusB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00073, ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK46918.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK46918.1; ALT_FRAME; Genomic_DNA.
DR   PIR; A70658; A70658.
DR   RefSeq; WP_003899364.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WIV0; -.
DR   SMR; P9WIV0; -.
DR   EnsemblBacteria; AAK46918; AAK46918; MT2608.
DR   KEGG; mtc:MT2608; -.
DR   PATRIC; fig|83331.31.peg.2814; -.
DR   HOGENOM; CLU_959168_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.940.10; -; 1.
DR   HAMAP; MF_00073; NusB; 1.
DR   InterPro; IPR035926; NusB-like_sf.
DR   InterPro; IPR011605; NusB_fam.
DR   InterPro; IPR006027; NusB_RsmB_TIM44.
DR   PANTHER; PTHR11078; PTHR11078; 1.
DR   Pfam; PF01029; NusB; 1.
DR   SUPFAM; SSF48013; SSF48013; 1.
DR   TIGRFAMs; TIGR01951; nusB; 1.
PE   3: Inferred from homology;
KW   RNA-binding; Transcription; Transcription antitermination;
KW   Transcription regulation.
FT   CHAIN           1..156
FT                   /note="Transcription antitermination protein NusB"
FT                   /id="PRO_0000427941"
SQ   SEQUENCE   156 AA;  16740 MW;  84923E642CA5FD15 CRC64;
     MSDRKPVRGR HQARKRAVAL LFEAEVRGIS AAEVVDTRAA LAEAKPDIAR LHPYTAAVAR
     GVSEHAAHID DLITAHLRGW TLDRLPAVDR AILRVSVWEL LHAADVPEPV VVDEAVQLAK
     ELSTDDSPGF VNGVLGQVML VTPQLRAAAQ AVRGGA