ID   ARPC2_ANOGA             Reviewed;         304 AA.
AC   Q7PVX8; Q7PVX9;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 2.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Probable actin-related protein 2/3 complex subunit 2;
DE   AltName: Full=Arp2/3 complex 34 kDa subunit;
DE            Short=p34-ARC;
GN   Name=Arc-p34; ORFNames=AGAP009154;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
CC       which is involved in regulation of actin polymerization and together
CC       with an activating nucleation-promoting factor (NPF) mediates the
CC       formation of branched actin networks. Seems to contact the mother actin
CC       filament (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Arp2/3 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARPC2 family. {ECO:0000305}.
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DR   EMBL; AAAB01008984; EAA14760.3; -; Genomic_DNA.
DR   RefSeq; XP_319914.2; XM_319914.3.
DR   AlphaFoldDB; Q7PVX8; -.
DR   SMR; Q7PVX8; -.
DR   STRING; 7165.AGAP009154-PA; -.
DR   PaxDb; Q7PVX8; -.
DR   GeneID; 1280110; -.
DR   KEGG; aga:AgaP_AGAP009154; -.
DR   CTD; 1280110; -.
DR   VEuPathDB; VectorBase:AGAP009154; -.
DR   eggNOG; KOG2826; Eukaryota.
DR   HOGENOM; CLU_059439_2_0_1; -.
DR   InParanoid; Q7PVX8; -.
DR   OMA; GPYIVSP; -.
DR   OrthoDB; 1345377at2759; -.
DR   PhylomeDB; Q7PVX8; -.
DR   Proteomes; UP000007062; Chromosome 3R.
DR   GO; GO:0005885; C:Arp2/3 protein complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR   GO; GO:0030041; P:actin filament polymerization; IEA:InterPro.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 3.30.1460.20; -; 2.
DR   InterPro; IPR007188; ARPC2.
DR   InterPro; IPR034666; ARPC2/4.
DR   PANTHER; PTHR12058; PTHR12058; 1.
DR   Pfam; PF04045; P34-Arc; 1.
DR   SUPFAM; SSF69645; SSF69645; 2.
PE   3: Inferred from homology;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..304
FT                   /note="Probable actin-related protein 2/3 complex subunit
FT                   2"
FT                   /id="PRO_0000124038"
SQ   SEQUENCE   304 AA;  35075 MW;  3E5700330C1C9008 CRC64;
     MILLEINNRI VEETLTVKFK NAIAGNKAES IDVTVADFDG VLFHISNING DKTKVRTSIS
     LKFYKQLQEH GADELLKREY GDLLVAPEDG YNVSVLVDLE NIPENWEETV RKIGLLKRNC
     FASVFEKYFD FQSQGEGEGE GQKRAVINYR NDETMYVEAK PDRVTVVFST IFRDEDDVVL
     GKVFMQELRE GRRASHTAPQ VLFSHREPPL ELANTGARVG ENIGYVTFVL FPRHTAKETR
     DNTINLIHMF RDYLHYHIKC SKAYIHSRMR AKTTEFLKVL NRARPEPKIT EKKTITGRTF
     IRKE