ID   ARPC2_CAEEL             Reviewed;         301 AA.
AC   Q8WTM6;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Probable actin-related protein 2/3 complex subunit 2;
DE   AltName: Full=Arp2/3 complex 34 kDa subunit;
DE            Short=p34-ARC;
GN   Name=arx-4; ORFNames=Y6D11A.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
CC       which is involved in regulation of actin polymerization and together
CC       with an activating nucleation-promoting factor (NPF) mediates the
CC       formation of branched actin networks. Seems to contact the mother actin
CC       filament (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Arp2/3 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARPC2 family. {ECO:0000305}.
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DR   EMBL; FO081578; CCD72538.1; -; Genomic_DNA.
DR   RefSeq; NP_741088.1; NM_171077.5.
DR   AlphaFoldDB; Q8WTM6; -.
DR   SMR; Q8WTM6; -.
DR   BioGRID; 40516; 7.
DR   STRING; 6239.Y6D11A.2; -.
DR   EPD; Q8WTM6; -.
DR   PaxDb; Q8WTM6; -.
DR   PeptideAtlas; Q8WTM6; -.
DR   EnsemblMetazoa; Y6D11A.2.1; Y6D11A.2.1; WBGene00021170.
DR   GeneID; 175247; -.
DR   UCSC; Y6D11A.2; c. elegans.
DR   CTD; 175247; -.
DR   WormBase; Y6D11A.2; CE30060; WBGene00021170; arx-4.
DR   eggNOG; KOG2826; Eukaryota.
DR   GeneTree; ENSGT00390000016794; -.
DR   HOGENOM; CLU_059439_1_0_1; -.
DR   InParanoid; Q8WTM6; -.
DR   OMA; GPYIVSP; -.
DR   OrthoDB; 1345377at2759; -.
DR   PhylomeDB; Q8WTM6; -.
DR   Reactome; R-CEL-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR   Reactome; R-CEL-3928662; EPHB-mediated forward signaling.
DR   Reactome; R-CEL-5663213; RHO GTPases Activate WASPs and WAVEs.
DR   Reactome; R-CEL-8856828; Clathrin-mediated endocytosis.
DR   PRO; PR:Q8WTM6; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00021170; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005885; C:Arp2/3 protein complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR   GO; GO:0030041; P:actin filament polymerization; IEA:InterPro.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR   GO; GO:0010631; P:epithelial cell migration; IMP:WormBase.
DR   GO; GO:0016331; P:morphogenesis of embryonic epithelium; IMP:WormBase.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 3.30.1460.20; -; 2.
DR   InterPro; IPR007188; ARPC2.
DR   InterPro; IPR034666; ARPC2/4.
DR   PANTHER; PTHR12058; PTHR12058; 1.
DR   Pfam; PF04045; P34-Arc; 1.
DR   SUPFAM; SSF69645; SSF69645; 2.
PE   3: Inferred from homology;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..301
FT                   /note="Probable actin-related protein 2/3 complex subunit
FT                   2"
FT                   /id="PRO_0000124037"
SQ   SEQUENCE   301 AA;  34480 MW;  DAAF36CC1CFE462F CRC64;
     MIILEQNNRI IVELLEQKFA NAKEGGKPES VNVTFADFDG VLYKLSNPDG DRTKIILSIS
     LKFYTELQQH GADDLLRRVY GGHMRSTPEQ GFNVTLEYNL ADLPADTTDL VQAASALKRN
     CFASVFEKYF EFQEAGQEGH KRAVINYRDD ETMYIEAKAD RVTVIFSTVF KDADDVIIGK
     VFLQEFREGR KASQTAPAVL YSLGEPPLEL KDLPEARVGD NVGYITFVLF PRHTNKKTKD
     NTIDLIHSFR DYLHYHIKCS KVYLHTRMRA KTTDFLKVLN RARPEVKGEK KTFHGRTFQT
     Q