ID   ARPC2_PONAB             Reviewed;         300 AA.
AC   Q5R5Z5;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Actin-related protein 2/3 complex subunit 2;
DE   AltName: Full=Arp2/3 complex 34 kDa subunit;
DE            Short=p34-ARC;
GN   Name=ARPC2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Actin-binding component of the Arp2/3 complex, a multiprotein
CC       complex that mediates actin polymerization upon stimulation by
CC       nucleation-promoting factor (NPF). The Arp2/3 complex mediates the
CC       formation of branched actin networks in the cytoplasm, providing the
CC       force for cell motility. Seems to contact the mother actin filament. In
CC       addition to its role in the cytoplasmic cytoskeleton, the Arp2/3
CC       complex also promotes actin polymerization in the nucleus, thereby
CC       regulating gene transcription and repair of damaged DNA. The Arp2/3
CC       complex promotes homologous recombination (HR) repair in response to
CC       DNA damage by promoting nuclear actin polymerization, leading to drive
CC       motility of double-strand breaks (DSBs).
CC       {ECO:0000250|UniProtKB:O15144}.
CC   -!- SUBUNIT: Component of the Arp2/3 complex composed of ACTR2/ARP2,
CC       ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC
CC       and ARPC5/p16-ARC (By similarity). Interacts with SHANK3; the
CC       interaction probably mediates the association of SHANK3 with the Arp2/3
CC       complex (By similarity). Interacts with DNAI3; this interaction reduces
CC       binding of the Arp2/3 complex to the VCA domain of nucleation promoting
CC       factors (By similarity). {ECO:0000250|UniProtKB:O15144,
CC       ECO:0000250|UniProtKB:P61160, ECO:0000250|UniProtKB:Q9CVB6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:O15144}. Cell projection
CC       {ECO:0000250|UniProtKB:O15144}. Synapse, synaptosome
CC       {ECO:0000250|UniProtKB:Q9CVB6}. Nucleus {ECO:0000250|UniProtKB:O15144}.
CC   -!- SIMILARITY: Belongs to the ARPC2 family. {ECO:0000305}.
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DR   EMBL; CR860705; CAH92821.1; -; mRNA.
DR   RefSeq; NP_001126648.1; NM_001133176.1.
DR   AlphaFoldDB; Q5R5Z5; -.
DR   SMR; Q5R5Z5; -.
DR   STRING; 9601.ENSPPYP00000014708; -.
DR   Ensembl; ENSPPYT00000062282; ENSPPYP00000041735; ENSPPYG00000013164.
DR   GeneID; 100173646; -.
DR   KEGG; pon:100173646; -.
DR   CTD; 10109; -.
DR   eggNOG; KOG2826; Eukaryota.
DR   GeneTree; ENSGT00390000016794; -.
DR   HOGENOM; CLU_059439_2_0_1; -.
DR   InParanoid; Q5R5Z5; -.
DR   OMA; GPYIVSP; -.
DR   OrthoDB; 1345377at2759; -.
DR   TreeFam; TF315006; -.
DR   Proteomes; UP000001595; Chromosome 2B.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005885; C:Arp2/3 protein complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0035861; C:site of double-strand break; ISS:UniProtKB.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030041; P:actin filament polymerization; IEA:InterPro.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 3.30.1460.20; -; 2.
DR   InterPro; IPR007188; ARPC2.
DR   InterPro; IPR034666; ARPC2/4.
DR   PANTHER; PTHR12058; PTHR12058; 1.
DR   Pfam; PF04045; P34-Arc; 1.
DR   SUPFAM; SSF69645; SSF69645; 2.
PE   2: Evidence at transcript level;
KW   Acetylation; Actin-binding; Cell projection; Cytoplasm; Cytoskeleton;
KW   Nucleus; Reference proteome; Synapse; Synaptosome.
FT   CHAIN           1..300
FT                   /note="Actin-related protein 2/3 complex subunit 2"
FT                   /id="PRO_0000124035"
FT   MOD_RES         275
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:O15144"
FT   MOD_RES         295
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:O15144"
SQ   SEQUENCE   300 AA;  34333 MW;  3BA57121BE9A05F2 CRC64;
     MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG DKTKVMVSIS
     LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE NLPASKDSIV HQAGMLKRNC
     FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE TMYVESKKDR VTVVFSTVFK DDDDVVIGKV
     FMQEFKEGRR ASHTAPQVLF SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT
     INLIHTFRDY LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR