ID   NUSB_STRP1              Reviewed;         150 AA.
AC   Q99Y88; Q48WW2;
DT   02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2015, sequence version 2.
DT   25-MAY-2022, entry version 131.
DE   RecName: Full=Transcription antitermination protein NusB {ECO:0000255|HAMAP-Rule:MF_00073};
DE   AltName: Full=Antitermination factor NusB {ECO:0000255|HAMAP-Rule:MF_00073};
GN   Name=nusB {ECO:0000255|HAMAP-Rule:MF_00073};
GN   OrderedLocusNames=SPy_1818, M5005_Spy1545;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   SEQUENCE REVISION TO 107 AND 121.
RA   Beres S.B., Musser J.M.;
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: Involved in transcription antitermination. Required for
CC       transcription of ribosomal RNA (rRNA) genes. Binds specifically to the
CC       boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
CC       {ECO:0000255|HAMAP-Rule:MF_00073}.
CC   -!- SIMILARITY: Belongs to the NusB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00073}.
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DR   EMBL; AE004092; AAK34543.2; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ52163.1; -; Genomic_DNA.
DR   RefSeq; NP_269822.2; NC_002737.2.
DR   AlphaFoldDB; Q99Y88; -.
DR   SMR; Q99Y88; -.
DR   STRING; 1314.HKU360_01595; -.
DR   PaxDb; Q99Y88; -.
DR   EnsemblBacteria; AAK34543; AAK34543; SPy_1818.
DR   KEGG; spy:SPy_1818; -.
DR   KEGG; spz:M5005_Spy1545; -.
DR   PATRIC; fig|160490.10.peg.1580; -.
DR   HOGENOM; CLU_087843_3_2_9; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.940.10; -; 1.
DR   HAMAP; MF_00073; NusB; 1.
DR   InterPro; IPR035926; NusB-like_sf.
DR   InterPro; IPR011605; NusB_fam.
DR   InterPro; IPR006027; NusB_RsmB_TIM44.
DR   PANTHER; PTHR11078; PTHR11078; 1.
DR   Pfam; PF01029; NusB; 1.
DR   SUPFAM; SSF48013; SSF48013; 1.
DR   TIGRFAMs; TIGR01951; nusB; 1.
PE   3: Inferred from homology;
KW   Reference proteome; RNA-binding; Transcription;
KW   Transcription antitermination; Transcription regulation.
FT   CHAIN           1..150
FT                   /note="Transcription antitermination protein NusB"
FT                   /id="PRO_0000176592"
SQ   SEQUENCE   150 AA;  16907 MW;  C9EB8BBB21EF261F CRC64;
     MTNSFQNSRR DLRERAFQAL FNIEMGAELL AASQFAYGYD KVTGEDAQVL ELPIFLLSLV
     TGVNNHKEEL DNLISTHLKK GWSLERLTLT DKTLLRLGLF EIKYFDETPD RVALNEIIEV
     AKKYSDETSA KFINGLLSQY VSGAPSANKS