ID   NUSB_STRP2              Reviewed;         140 AA.
AC   Q04M45;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Transcription antitermination protein NusB {ECO:0000255|HAMAP-Rule:MF_00073};
DE   AltName: Full=Antitermination factor NusB {ECO:0000255|HAMAP-Rule:MF_00073};
GN   Name=nusB {ECO:0000255|HAMAP-Rule:MF_00073}; OrderedLocusNames=SPD_0393;
OS   Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=373153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D39 / NCTC 7466;
RX   PubMed=17041037; DOI=10.1128/jb.01148-06;
RA   Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M.,
RA   Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.;
RT   "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus
RT   pneumoniae and comparison with that of unencapsulated laboratory strain
RT   R6.";
RL   J. Bacteriol. 189:38-51(2007).
CC   -!- FUNCTION: Involved in transcription antitermination. Required for
CC       transcription of ribosomal RNA (rRNA) genes. Binds specifically to the
CC       boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
CC       {ECO:0000255|HAMAP-Rule:MF_00073}.
CC   -!- SIMILARITY: Belongs to the NusB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00073}.
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DR   EMBL; CP000410; ABJ54523.1; -; Genomic_DNA.
DR   RefSeq; WP_000203654.1; NC_008533.2.
DR   AlphaFoldDB; Q04M45; -.
DR   SMR; Q04M45; -.
DR   STRING; 373153.SPD_0393; -.
DR   EnsemblBacteria; ABJ54523; ABJ54523; SPD_0393.
DR   GeneID; 60232910; -.
DR   GeneID; 66805621; -.
DR   KEGG; spd:SPD_0393; -.
DR   eggNOG; COG0781; Bacteria.
DR   HOGENOM; CLU_087843_3_2_9; -.
DR   OMA; DRMPVVD; -.
DR   OrthoDB; 1574817at2; -.
DR   BioCyc; SPNE373153:G1G6V-432-MON; -.
DR   Proteomes; UP000001452; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.940.10; -; 1.
DR   HAMAP; MF_00073; NusB; 1.
DR   InterPro; IPR035926; NusB-like_sf.
DR   InterPro; IPR011605; NusB_fam.
DR   InterPro; IPR006027; NusB_RsmB_TIM44.
DR   PANTHER; PTHR11078; PTHR11078; 1.
DR   Pfam; PF01029; NusB; 1.
DR   SUPFAM; SSF48013; SSF48013; 1.
DR   TIGRFAMs; TIGR01951; nusB; 1.
PE   3: Inferred from homology;
KW   RNA-binding; Transcription; Transcription antitermination;
KW   Transcription regulation.
FT   CHAIN           1..140
FT                   /note="Transcription antitermination protein NusB"
FT                   /id="PRO_1000023779"
SQ   SEQUENCE   140 AA;  15964 MW;  20B646B25D3511FC CRC64;
     MTSPLLESRR QLRKCAFQAL MSLEFGTDVE TACRFAYTHD REDTDVQLPA FLIDLVSGVQ
     AKKEELDKQI TQHLKAGWTI ERLTLVERNL LRLGVFEITS FDTPQLVAVN EAIELAKDFS
     DQKSARFING LLSQFVTEEQ