ID   NUSB_STRP6              Reviewed;         150 AA.
AC   Q5XA94;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Transcription antitermination protein NusB {ECO:0000255|HAMAP-Rule:MF_00073};
DE   AltName: Full=Antitermination factor NusB {ECO:0000255|HAMAP-Rule:MF_00073};
GN   Name=nusB {ECO:0000255|HAMAP-Rule:MF_00073}; OrderedLocusNames=M6_Spy1534;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
CC   -!- FUNCTION: Involved in transcription antitermination. Required for
CC       transcription of ribosomal RNA (rRNA) genes. Binds specifically to the
CC       boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
CC       {ECO:0000255|HAMAP-Rule:MF_00073}.
CC   -!- SIMILARITY: Belongs to the NusB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00073}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT87669.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000003; AAT87669.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_002983167.1; NC_006086.1.
DR   AlphaFoldDB; Q5XA94; -.
DR   SMR; Q5XA94; -.
DR   EnsemblBacteria; AAT87669; AAT87669; M6_Spy1534.
DR   GeneID; 57853230; -.
DR   KEGG; spa:M6_Spy1534; -.
DR   HOGENOM; CLU_087843_3_2_9; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.940.10; -; 1.
DR   HAMAP; MF_00073; NusB; 1.
DR   InterPro; IPR035926; NusB-like_sf.
DR   InterPro; IPR011605; NusB_fam.
DR   InterPro; IPR006027; NusB_RsmB_TIM44.
DR   PANTHER; PTHR11078; PTHR11078; 1.
DR   Pfam; PF01029; NusB; 1.
DR   SUPFAM; SSF48013; SSF48013; 1.
DR   TIGRFAMs; TIGR01951; nusB; 1.
PE   3: Inferred from homology;
KW   RNA-binding; Transcription; Transcription antitermination;
KW   Transcription regulation.
FT   CHAIN           1..150
FT                   /note="Transcription antitermination protein NusB"
FT                   /id="PRO_0000176594"
SQ   SEQUENCE   150 AA;  16949 MW;  93EB8BAC11E11605 CRC64;
     MTNSFQNSRR DLRERAFQAL FNIETGAELL AASQFAYGYD KVTGEDAQVL ELPIFLLSLV
     TGVNNHKEEL DNLISTHLKK GWSLERLTLT DKTLLRLGLF EIKYFDETPD RVALNEIIEV
     AKKYSDETSA KFINGLLSQY VSEAPSANKS