ID   NUSB_STRPN              Reviewed;         140 AA.
AC   P65582; Q97SF0;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Transcription antitermination protein NusB {ECO:0000255|HAMAP-Rule:MF_00073};
DE   AltName: Full=Antitermination factor NusB {ECO:0000255|HAMAP-Rule:MF_00073};
GN   Name=nusB {ECO:0000255|HAMAP-Rule:MF_00073}; OrderedLocusNames=SP_0433;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Involved in transcription antitermination. Required for
CC       transcription of ribosomal RNA (rRNA) genes. Binds specifically to the
CC       boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
CC       {ECO:0000255|HAMAP-Rule:MF_00073}.
CC   -!- INTERACTION:
CC       P65582; A0A0H2UPA1: SP_0767; NbExp=2; IntAct=EBI-6474808, EBI-6474805;
CC   -!- SIMILARITY: Belongs to the NusB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00073}.
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DR   EMBL; AE005672; AAK74595.1; -; Genomic_DNA.
DR   PIR; B95050; B95050.
DR   RefSeq; WP_000203654.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P65582; -.
DR   SMR; P65582; -.
DR   IntAct; P65582; 1.
DR   STRING; 170187.SP_0433; -.
DR   EnsemblBacteria; AAK74595; AAK74595; SP_0433.
DR   GeneID; 60232910; -.
DR   GeneID; 66805621; -.
DR   KEGG; spn:SP_0433; -.
DR   eggNOG; COG0781; Bacteria.
DR   OMA; DRMPVVD; -.
DR   PhylomeDB; P65582; -.
DR   BioCyc; SPNE170187:G1FZB-448-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.940.10; -; 1.
DR   HAMAP; MF_00073; NusB; 1.
DR   InterPro; IPR035926; NusB-like_sf.
DR   InterPro; IPR011605; NusB_fam.
DR   InterPro; IPR006027; NusB_RsmB_TIM44.
DR   PANTHER; PTHR11078; PTHR11078; 1.
DR   Pfam; PF01029; NusB; 1.
DR   SUPFAM; SSF48013; SSF48013; 1.
DR   TIGRFAMs; TIGR01951; nusB; 1.
PE   1: Evidence at protein level;
KW   RNA-binding; Transcription; Transcription antitermination;
KW   Transcription regulation.
FT   CHAIN           1..140
FT                   /note="Transcription antitermination protein NusB"
FT                   /id="PRO_0000176590"
SQ   SEQUENCE   140 AA;  15964 MW;  20B646B25D3511FC CRC64;
     MTSPLLESRR QLRKCAFQAL MSLEFGTDVE TACRFAYTHD REDTDVQLPA FLIDLVSGVQ
     AKKEELDKQI TQHLKAGWTI ERLTLVERNL LRLGVFEITS FDTPQLVAVN EAIELAKDFS
     DQKSARFING LLSQFVTEEQ