NUSB_THEMA
ID NUSB_THEMA Reviewed; 142 AA.
AC Q9X286;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Transcription antitermination protein NusB {ECO:0000255|HAMAP-Rule:MF_00073};
DE AltName: Full=Antitermination factor NusB {ECO:0000255|HAMAP-Rule:MF_00073, ECO:0000303|PubMed:15279620};
GN Name=nusB {ECO:0000255|HAMAP-Rule:MF_00073}; OrderedLocusNames=TM_1765;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
RN [2] {ECO:0007744|PDB:1TZT, ECO:0007744|PDB:1TZU, ECO:0007744|PDB:1TZV, ECO:0007744|PDB:1TZW, ECO:0007744|PDB:1TZX}
RP X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS), SUBUNIT, AND RNA-BINDING.
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=15279620; DOI=10.1042/bj20040889;
RA Bonin I., Robelek R., Benecke H., Urlaub H., Bacher A., Richter G.,
RA Wahl M.C.;
RT "Crystal structures of the antitermination factor NusB from Thermotoga
RT maritima and implications for RNA binding.";
RL Biochem. J. 383:419-428(2004).
CC -!- FUNCTION: Involved in transcription antitermination. Required for
CC transcription of ribosomal RNA (rRNA) genes. Binds specifically to the
CC boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
CC {ECO:0000255|HAMAP-Rule:MF_00073}.
CC -!- SUBUNIT: Monomer or homodimer; in equilibrium, with a preference for
CC the monomer. Dimerization may be employed to package NusB in an
CC inactive form until recruitment into antitermination complexes.
CC {ECO:0000269|PubMed:15279620}.
CC -!- SIMILARITY: Belongs to the NusB family. {ECO:0000255|HAMAP-
CC Rule:MF_00073, ECO:0000305}.
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DR EMBL; AE000512; AAD36829.1; -; Genomic_DNA.
DR PIR; D72212; D72212.
DR RefSeq; NP_229562.1; NC_000853.1.
DR RefSeq; WP_004082311.1; NZ_CP011107.1.
DR PDB; 1TZT; X-ray; 1.55 A; A/B=1-142.
DR PDB; 1TZU; X-ray; 1.85 A; A=1-142.
DR PDB; 1TZV; X-ray; 1.35 A; A=1-142.
DR PDB; 1TZW; X-ray; 1.60 A; A=1-142.
DR PDB; 1TZX; X-ray; 1.72 A; A/B=1-142.
DR PDBsum; 1TZT; -.
DR PDBsum; 1TZU; -.
DR PDBsum; 1TZV; -.
DR PDBsum; 1TZW; -.
DR PDBsum; 1TZX; -.
DR AlphaFoldDB; Q9X286; -.
DR SMR; Q9X286; -.
DR STRING; 243274.THEMA_05400; -.
DR DrugBank; DB04272; Citric acid.
DR EnsemblBacteria; AAD36829; AAD36829; TM_1765.
DR KEGG; tma:TM1765; -.
DR eggNOG; COG0781; Bacteria.
DR InParanoid; Q9X286; -.
DR OMA; DRMPVVD; -.
DR OrthoDB; 1574817at2; -.
DR EvolutionaryTrace; Q9X286; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-KW.
DR Gene3D; 1.10.940.10; -; 1.
DR HAMAP; MF_00073; NusB; 1.
DR InterPro; IPR035926; NusB-like_sf.
DR InterPro; IPR011605; NusB_fam.
DR InterPro; IPR006027; NusB_RsmB_TIM44.
DR PANTHER; PTHR11078; PTHR11078; 1.
DR Pfam; PF01029; NusB; 1.
DR SUPFAM; SSF48013; SSF48013; 1.
DR TIGRFAMs; TIGR01951; nusB; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; RNA-binding; Transcription;
KW Transcription antitermination; Transcription regulation.
FT CHAIN 1..142
FT /note="Transcription antitermination protein NusB"
FT /id="PRO_0000176599"
FT HELIX 5..19
FT /evidence="ECO:0007829|PDB:1TZV"
FT HELIX 27..34
FT /evidence="ECO:0007829|PDB:1TZV"
FT HELIX 41..56
FT /evidence="ECO:0007829|PDB:1TZV"
FT HELIX 58..66
FT /evidence="ECO:0007829|PDB:1TZV"
FT STRAND 70..72
FT /evidence="ECO:0007829|PDB:1TZV"
FT HELIX 74..76
FT /evidence="ECO:0007829|PDB:1TZV"
FT HELIX 79..94
FT /evidence="ECO:0007829|PDB:1TZV"
FT HELIX 100..114
FT /evidence="ECO:0007829|PDB:1TZV"
FT HELIX 117..134
FT /evidence="ECO:0007829|PDB:1TZV"
FT HELIX 137..139
FT /evidence="ECO:0007829|PDB:1TZV"
SQ SEQUENCE 142 AA; 16974 MW; 54C75FC72D2BEE0F CRC64;
MKTPRRRMRL AVFKALFQHE FRRDEDLEQI LEEILDETYD KKAKEDARRY IRGIKENLSM
IDDLISRYLE KWSLNRLSVV DRNVLRLATY ELLFEKDIPI EVTIDEAIEI AKRYGTENSG
KFVNGILDRI AKEHAPKEKF EL