ID   ARPC3_ENTHI             Reviewed;         128 AA.
AC   O15604;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Probable actin-related protein 2/3 complex subunit 3;
DE   AltName: Full=Arp2/3 complex 21 kDa subunit;
DE            Short=p21-ARC;
DE   Flags: Fragment;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ATCC 30459 / HM-1:IMSS;
RX   PubMed=9245698; DOI=10.1006/bbrc.1997.7019;
RA   Tanaka T., Tanaka M., Mitsui Y.;
RT   "Analysis of expressed sequence tags (ESTs) of the parasitic protozoa
RT   Entamoeba histolytica.";
RL   Biochem. Biophys. Res. Commun. 236:611-615(1997).
CC   -!- FUNCTION: Functions as component of the Arp2/3 complex which is
CC       involved in regulation of actin polymerization and together with an
CC       activating nucleation-promoting factor (NPF) mediates the formation of
CC       branched actin networks. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Arp2/3 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARPC3 family. {ECO:0000305}.
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DR   EMBL; AB002759; BAA21999.1; -; mRNA.
DR   AlphaFoldDB; O15604; -.
DR   SMR; O15604; -.
DR   STRING; 5759.rna_EHI_174910-1; -.
DR   VEuPathDB; AmoebaDB:EHI5A_075410; -.
DR   VEuPathDB; AmoebaDB:EHI_174910; -.
DR   VEuPathDB; AmoebaDB:KM1_236740; -.
DR   eggNOG; KOG3155; Eukaryota.
DR   GO; GO:0005885; C:Arp2/3 protein complex; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 1.10.1760.10; -; 1.
DR   InterPro; IPR007204; ARPC3.
DR   InterPro; IPR036753; ARPC3_sf.
DR   PANTHER; PTHR12391; PTHR12391; 1.
DR   Pfam; PF04062; P21-Arc; 1.
DR   SUPFAM; SSF69060; SSF69060; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton.
FT   CHAIN           <1..>128
FT                   /note="Probable actin-related protein 2/3 complex subunit
FT                   3"
FT                   /id="PRO_0000124046"
FT   NON_TER         1
FT   NON_TER         128
SQ   SEQUENCE   128 AA;  14427 MW;  80D9434B2180C515 CRC64;
     IFMKRSGAYH SELDKDIVQK AGNFPLMQFK TKVKVNPKFL LKGDDMDIVD EAITYYKANV
     FYKNLDMSIC EADKLLAYLM FYLQSLLLTF TGRTKVDCDK MAFSLAIENF GLPGDGKFCL
     GGIADPPT