ID   NUSG_BUCBP              Reviewed;         181 AA.
AC   Q89B15;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2003, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Transcription termination/antitermination protein NusG {ECO:0000255|HAMAP-Rule:MF_00948};
GN   Name=nusG {ECO:0000255|HAMAP-Rule:MF_00948}; OrderedLocusNames=bbp_040;
OS   Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=224915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bp;
RX   PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA   van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA   Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA   Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT   "Reductive genome evolution in Buchnera aphidicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC   -!- FUNCTION: Participates in transcription elongation, termination and
CC       antitermination. In the absence of Rho, increases the rate of
CC       transcription elongation by the RNA polymerase (RNAP), probably by
CC       partially suppressing pausing. In the presence of Rho, modulates most
CC       Rho-dependent termination events by interacting with the RNAP to render
CC       the complex more susceptible to the termination activity of Rho. May be
CC       required to overcome a kinetic limitation of Rho to function at certain
CC       terminators. Also involved in ribosomal RNA transcriptional
CC       antitermination. {ECO:0000255|HAMAP-Rule:MF_00948}.
CC   -!- SUBUNIT: Monomer. Interacts with the transcription termination factor
CC       Rho and with RNA polymerase. {ECO:0000255|HAMAP-Rule:MF_00948}.
CC   -!- SIMILARITY: Belongs to the NusG family. {ECO:0000255|HAMAP-
CC       Rule:MF_00948}.
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DR   EMBL; AE016826; AAO26783.1; -; Genomic_DNA.
DR   RefSeq; WP_011091184.1; NC_004545.1.
DR   AlphaFoldDB; Q89B15; -.
DR   SMR; Q89B15; -.
DR   STRING; 224915.bbp_040; -.
DR   PRIDE; Q89B15; -.
DR   EnsemblBacteria; AAO26783; AAO26783; bbp_040.
DR   GeneID; 56470584; -.
DR   KEGG; bab:bbp_040; -.
DR   eggNOG; COG0250; Bacteria.
DR   HOGENOM; CLU_067287_1_0_6; -.
DR   OMA; DGPFNGF; -.
DR   OrthoDB; 2027986at2; -.
DR   Proteomes; UP000000601; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0006354; P:DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:InterPro.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 3.30.70.940; -; 1.
DR   HAMAP; MF_00948; NusG; 1.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR006645; NGN_dom.
DR   InterPro; IPR036735; NGN_dom_sf.
DR   InterPro; IPR043425; NusG-like.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR001062; Transcrpt_antiterm_NusG.
DR   InterPro; IPR015869; Transcrpt_antiterm_NusG_bac_CS.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR30265; PTHR30265; 1.
DR   PANTHER; PTHR30265:SF2; PTHR30265:SF2; 1.
DR   Pfam; PF00467; KOW; 1.
DR   Pfam; PF02357; NusG; 1.
DR   PRINTS; PR00338; NUSGTNSCPFCT.
DR   SMART; SM00739; KOW; 1.
DR   SMART; SM00738; NGN; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   SUPFAM; SSF82679; SSF82679; 1.
DR   TIGRFAMs; TIGR00922; nusG; 1.
DR   PROSITE; PS01014; NUSG; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transcription; Transcription antitermination;
KW   Transcription regulation; Transcription termination.
FT   CHAIN           1..181
FT                   /note="Transcription termination/antitermination protein
FT                   NusG"
FT                   /id="PRO_0000113920"
FT   DOMAIN          130..158
FT                   /note="KOW"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00948"
SQ   SEQUENCE   181 AA;  20901 MW;  11AD12C15E46EF5A CRC64;
     MYKSYKKRWY VLQAFSGFEG RIAQSIREHV KLKKMEKLFG EVMVPSEEVI EIKAGQRKKS
     EYKFFPGYVL IQMIMNESSW HLVRSIPRVL GFIGGTPDRP LPITDQEVNT IINKLKQVGD
     KPRPKTLFEP GETVRVNDGP FSDFNGIVEE VDYEKNRLKV SVSIFGRSTP VELDFSQVKK
     N