ARPC4_CAEEL
ID ARPC4_CAEEL Reviewed; 169 AA.
AC P58798; Q18491; Q95QS0;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2002, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Probable actin-related protein 2/3 complex subunit 4;
DE AltName: Full=Arp2/3 complex 20 kDa subunit;
DE Short=p20-ARC;
GN Name=arx-6; ORFNames=C35D10.16;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
CC which is involved in regulation of actin polymerization and together
CC with an activating nucleation-promoting factor (NPF) mediates the
CC formation of branched actin networks. Seems to contact the mother actin
CC filament (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Arp2/3 complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ARPC4 family. {ECO:0000305}.
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DR EMBL; FO080789; CCD66789.1; -; Genomic_DNA.
DR RefSeq; NP_498020.1; NM_065619.4.
DR AlphaFoldDB; P58798; -.
DR SMR; P58798; -.
DR BioGRID; 40884; 9.
DR STRING; 6239.C35D10.16; -.
DR EPD; P58798; -.
DR PaxDb; P58798; -.
DR PeptideAtlas; P58798; -.
DR EnsemblMetazoa; C35D10.16.1; C35D10.16.1; WBGene00000204.
DR GeneID; 175650; -.
DR KEGG; cel:CELE_C35D10.16; -.
DR UCSC; C35D10.16; c. elegans.
DR CTD; 175650; -.
DR WormBase; C35D10.16; CE28899; WBGene00000204; arx-6.
DR eggNOG; KOG1876; Eukaryota.
DR GeneTree; ENSGT00390000016233; -.
DR HOGENOM; CLU_084855_1_0_1; -.
DR InParanoid; P58798; -.
DR OMA; EAYLGEF; -.
DR OrthoDB; 1351067at2759; -.
DR PhylomeDB; P58798; -.
DR Reactome; R-CEL-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-CEL-3928662; EPHB-mediated forward signaling.
DR Reactome; R-CEL-5663213; RHO GTPases Activate WASPs and WAVEs.
DR Reactome; R-CEL-8856828; Clathrin-mediated endocytosis.
DR PRO; PR:P58798; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000204; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005885; C:Arp2/3 protein complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0030041; P:actin filament polymerization; IEA:InterPro.
DR GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR GO; GO:0010631; P:epithelial cell migration; IMP:WormBase.
DR GO; GO:0016331; P:morphogenesis of embryonic epithelium; IMP:WormBase.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR Gene3D; 3.30.1460.20; -; 1.
DR InterPro; IPR034666; ARPC2/4.
DR InterPro; IPR008384; ARPC4.
DR PANTHER; PTHR22629; PTHR22629; 1.
DR Pfam; PF05856; ARPC4; 1.
DR PIRSF; PIRSF039100; ARPC4; 1.
DR SUPFAM; SSF69645; SSF69645; 1.
PE 3: Inferred from homology;
KW Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..169
FT /note="Probable actin-related protein 2/3 complex subunit
FT 4"
FT /id="PRO_0000124051"
SQ SEQUENCE 169 AA; 19663 MW; 3E15A4575CA10218 CRC64;
MSATLQPYLE AVRHTLQAAL CLEQFSSQVV ERHNKPEVEV QTSKELLMTP VVVARNKQER
VLIEPSVNSV RISIAIKQSD EIEKILCHKF TRFMCQRADN FFVLRRKPLP GYDISFLITA
SHTEAMFKHK LVDFLLHFMQ EIDKEISEMK LSLNARARVS AEEFLKRFN
