NUSG_STRCO
ID NUSG_STRCO Reviewed; 300 AA.
AC P36266; Q9L0L3;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 18-OCT-2001, sequence version 3.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Transcription termination/antitermination protein NusG {ECO:0000255|HAMAP-Rule:MF_00948};
GN Name=nusG {ECO:0000255|HAMAP-Rule:MF_00948}; OrderedLocusNames=SCO4647;
GN ORFNames=SCD82.18;
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=A3(2) / NRRL B-16638;
RX PubMed=8286423;
RA Miyake K., Onaka H., Horinouchi S., Beppu T.;
RT "Organization and nucleotide sequence of the secE-nusG region of
RT Streptomyces griseus.";
RL Biochim. Biophys. Acta 1217:97-100(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=A3(2) / NRRL B-16638;
RX PubMed=7715599; DOI=10.1007/bf00425829;
RA Puttikhunt C., Nihira T., Yamada Y.;
RT "Cloning, nucleotide sequence, and transcriptional analysis of the nusG
RT gene of Streptomyces coelicolor A3(2), which encodes a putative
RT transcriptional antiterminator.";
RL Mol. Gen. Genet. 247:118-122(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145;
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- FUNCTION: Participates in transcription elongation, termination and
CC antitermination. {ECO:0000255|HAMAP-Rule:MF_00948}.
CC -!- SIMILARITY: Belongs to the NusG family. {ECO:0000255|HAMAP-
CC Rule:MF_00948}.
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DR EMBL; D17465; BAA04282.1; -; Genomic_DNA.
DR EMBL; D32254; BAA06985.1; -; Genomic_DNA.
DR EMBL; AL939120; CAB77421.1; -; Genomic_DNA.
DR PIR; S41062; S41062.
DR PIR; S54717; S54717.
DR RefSeq; NP_628808.1; NC_003888.3.
DR RefSeq; WP_011029791.1; NZ_VNID01000028.1.
DR AlphaFoldDB; P36266; -.
DR SMR; P36266; -.
DR STRING; 100226.SCO4647; -.
DR GeneID; 1100088; -.
DR KEGG; sco:SCO4647; -.
DR PATRIC; fig|100226.15.peg.4718; -.
DR eggNOG; COG0250; Bacteria.
DR HOGENOM; CLU_067287_0_1_11; -.
DR InParanoid; P36266; -.
DR OMA; DGPFNGF; -.
DR PhylomeDB; P36266; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0006354; P:DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:InterPro.
DR GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 3.30.70.940; -; 1.
DR HAMAP; MF_00948; NusG; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR006645; NGN_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR043425; NusG-like.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR001062; Transcrpt_antiterm_NusG.
DR InterPro; IPR015869; Transcrpt_antiterm_NusG_bac_CS.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR30265; PTHR30265; 1.
DR PANTHER; PTHR30265:SF2; PTHR30265:SF2; 1.
DR Pfam; PF02357; NusG; 1.
DR PRINTS; PR00338; NUSGTNSCPFCT.
DR SMART; SM00739; KOW; 1.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
DR SUPFAM; SSF82679; SSF82679; 1.
DR TIGRFAMs; TIGR00922; nusG; 1.
DR PROSITE; PS01014; NUSG; 1.
PE 3: Inferred from homology;
KW Reference proteome; Transcription; Transcription antitermination;
KW Transcription regulation; Transcription termination.
FT CHAIN 1..300
FT /note="Transcription termination/antitermination protein
FT NusG"
FT /id="PRO_0000113956"
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..95
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 75..81
FT /note="ADADAAE -> RDQTRRK (in Ref. 1; BAA04282)"
FT /evidence="ECO:0000305"
FT CONFLICT 104..106
FT /note="QEL -> PGV (in Ref. 1; BAA04282)"
FT /evidence="ECO:0000305"
FT CONFLICT 105..106
FT /note="EL -> DV (in Ref. 2; BAA06985)"
FT /evidence="ECO:0000305"
FT CONFLICT 151
FT /note="E -> K (in Ref. 1; BAA04282)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="L -> Y (in Ref. 1; BAA04282)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 300 AA; 32845 MW; F7C69DBEE6431A53 CRC64;
MSDPNVNDAI EPVESVEDEL GTVEGADNED TEASAEAEAA DDTVVAETDE DATDAEADET
AEATDAEATE AEADADADAA EAEESEEEPE AEEPELDPIE KLRQELRVLP GEWYVIHTYA
GYENRVKTNL EQRAVSLNVE DYIFQAEVPQ EEVVQIKNGD RKTIRQNKLP GYVLVRMDLT
NESWGVVRNT PGVTGFVGNA YDPYPLTLDE IVKMLAPEAE EKAAREAAEA EGKPAPQRKV
EVQVLDFEVG DSVTVTDGPF ATLQATINEI NADSKKVKGL VEIFGRETPV ELSFDQIQKN
