ID   NUSG_STRGR              Reviewed;         294 AA.
AC   P36260;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Transcription termination/antitermination protein NusG {ECO:0000255|HAMAP-Rule:MF_00948};
GN   Name=nusG {ECO:0000255|HAMAP-Rule:MF_00948};
OS   Streptomyces griseus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=N2-3-11;
RX   PubMed=8039667; DOI=10.1111/j.1574-6968.1994.tb06863.x;
RA   Kuberski S., Kasberg T., Distler J.;
RT   "The nusG gene of Streptomyces griseus: cloning of the gene and analysis of
RT   the A-factor binding properties of the gene product.";
RL   FEMS Microbiol. Lett. 119:33-39(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IFO 13350 / CBS 651.72;
RX   PubMed=8286423;
RA   Miyake K., Onaka H., Horinouchi S., Beppu T.;
RT   "Organization and nucleotide sequence of the secE-nusG region of
RT   Streptomyces griseus.";
RL   Biochim. Biophys. Acta 1217:97-100(1994).
CC   -!- FUNCTION: Participates in transcription elongation, termination and
CC       antitermination. {ECO:0000255|HAMAP-Rule:MF_00948}.
CC   -!- SIMILARITY: Belongs to the NusG family. {ECO:0000255|HAMAP-
CC       Rule:MF_00948}.
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DR   EMBL; X72787; CAA51296.1; -; Genomic_DNA.
DR   EMBL; D17464; BAA04281.1; -; Genomic_DNA.
DR   PIR; S32234; S32234.
DR   PIR; S41061; S41061.
DR   RefSeq; WP_003967001.1; NZ_UAVD01000027.1.
DR   AlphaFoldDB; P36260; -.
DR   SMR; P36260; -.
DR   GeneID; 6209526; -.
DR   OMA; DGPFNGF; -.
DR   GO; GO:0006354; P:DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:InterPro.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 3.30.70.940; -; 1.
DR   HAMAP; MF_00948; NusG; 1.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR006645; NGN_dom.
DR   InterPro; IPR036735; NGN_dom_sf.
DR   InterPro; IPR043425; NusG-like.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR001062; Transcrpt_antiterm_NusG.
DR   InterPro; IPR015869; Transcrpt_antiterm_NusG_bac_CS.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR30265; PTHR30265; 1.
DR   PANTHER; PTHR30265:SF2; PTHR30265:SF2; 1.
DR   Pfam; PF02357; NusG; 1.
DR   PRINTS; PR00338; NUSGTNSCPFCT.
DR   SMART; SM00739; KOW; 1.
DR   SMART; SM00738; NGN; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   SUPFAM; SSF82679; SSF82679; 1.
DR   TIGRFAMs; TIGR00922; nusG; 1.
DR   PROSITE; PS01014; NUSG; 1.
PE   3: Inferred from homology;
KW   Transcription; Transcription antitermination; Transcription regulation;
KW   Transcription termination.
FT   CHAIN           1..294
FT                   /note="Transcription termination/antitermination protein
FT                   NusG"
FT                   /id="PRO_0000113958"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..87
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        84..88
FT                   /note="AEPAA -> RAGRR (in Ref. 2; BAA04281)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        285..286
FT                   /note="EL -> DV (in Ref. 2; BAA04281)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   294 AA;  31810 MW;  C51CD316DB4977F5 CRC64;
     MSDPNLNDAV EPEAGASESA KDELDIVEAA DSVDPDQAEA ADLAAGEPAE RAAVNVAGDD
     SDEDDAAAEE AVEADDESAD EEEAEPAAPV DPVAALRDEL RTLPGEWYVI HTYAGYEKRV
     KANLEQRAVS LNVEEFIYQA EVPEEEIVQI KNGERKNVRQ NKLPGYVLVR MDLTNESWGV
     VRNTPGVTGF VGNAYDPYPL TLDEIVKMLA PEAEEKAARE AAEAEGKPAP ARKVEVQVLD
     FEVGDSVTVT DGPFATLQAT INEINADSKK VKGLVEIFGR ETPVELSFDQ IQKN