NUSG_YERPE
ID NUSG_YERPE Reviewed; 181 AA.
AC Q8ZAP0; Q0WAQ6;
DT 16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Transcription termination/antitermination protein NusG {ECO:0000255|HAMAP-Rule:MF_00948};
GN Name=nusG {ECO:0000255|HAMAP-Rule:MF_00948};
GN OrderedLocusNames=YPO3752, y0479, YP_3115;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Participates in transcription elongation, termination and
CC antitermination. In the absence of Rho, increases the rate of
CC transcription elongation by the RNA polymerase (RNAP), probably by
CC partially suppressing pausing. In the presence of Rho, modulates most
CC Rho-dependent termination events by interacting with the RNAP to render
CC the complex more susceptible to the termination activity of Rho. May be
CC required to overcome a kinetic limitation of Rho to function at certain
CC terminators. Also involved in ribosomal RNA transcriptional
CC antitermination. {ECO:0000255|HAMAP-Rule:MF_00948}.
CC -!- SUBUNIT: Monomer. Interacts with the transcription termination factor
CC Rho and with RNA polymerase. {ECO:0000255|HAMAP-Rule:MF_00948}.
CC -!- SIMILARITY: Belongs to the NusG family. {ECO:0000255|HAMAP-
CC Rule:MF_00948}.
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DR EMBL; AL590842; CAL22339.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84068.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS63285.1; -; Genomic_DNA.
DR PIR; AH0456; AH0456.
DR RefSeq; WP_002210671.1; NZ_WUCM01000099.1.
DR RefSeq; YP_002348632.1; NC_003143.1.
DR AlphaFoldDB; Q8ZAP0; -.
DR SMR; Q8ZAP0; -.
DR STRING; 214092.YPO3752; -.
DR PaxDb; Q8ZAP0; -.
DR DNASU; 1145426; -.
DR EnsemblBacteria; AAM84068; AAM84068; y0479.
DR EnsemblBacteria; AAS63285; AAS63285; YP_3115.
DR GeneID; 61904467; -.
DR GeneID; 67422086; -.
DR KEGG; ype:YPO3752; -.
DR KEGG; ypk:y0479; -.
DR KEGG; ypm:YP_3115; -.
DR PATRIC; fig|214092.21.peg.4270; -.
DR eggNOG; COG0250; Bacteria.
DR HOGENOM; CLU_067287_1_0_6; -.
DR OMA; DGPFNGF; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0006354; P:DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:InterPro.
DR GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 3.30.70.940; -; 1.
DR HAMAP; MF_00948; NusG; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR006645; NGN_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR043425; NusG-like.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR001062; Transcrpt_antiterm_NusG.
DR InterPro; IPR015869; Transcrpt_antiterm_NusG_bac_CS.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR30265; PTHR30265; 1.
DR PANTHER; PTHR30265:SF2; PTHR30265:SF2; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF02357; NusG; 1.
DR PRINTS; PR00338; NUSGTNSCPFCT.
DR SMART; SM00739; KOW; 1.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
DR SUPFAM; SSF82679; SSF82679; 1.
DR TIGRFAMs; TIGR00922; nusG; 1.
DR PROSITE; PS01014; NUSG; 1.
PE 3: Inferred from homology;
KW Reference proteome; Transcription; Transcription antitermination;
KW Transcription regulation; Transcription termination.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..181
FT /note="Transcription termination/antitermination protein
FT NusG"
FT /id="PRO_0000113973"
FT DOMAIN 130..161
FT /note="KOW"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00948"
SQ SEQUENCE 181 AA; 20514 MW; C078FF359DFE1826 CRC64;
MSEAPKKRWY VVQAFSGFEG RVAQSLREHI KLHDMEELFG EVMVPTEEVV EIRGGQRRKS
ERKFFPGYVL VQMVMNDASW HLVRSVPRVM GFIGGTSDRP APISDKEVDA IMNRLQQVGD
KPRPKTLFEP GELVRVSDGP FADFNGVVEE VDYEKSRLKV SVSIFGRATP VELDFSQVEK
G
