NUTM1_HUMAN
ID NUTM1_HUMAN Reviewed; 1132 AA.
AC Q86Y26; B4DZ00; B7Z7Y4; E7EVE8; F5H4I6; Q86YS8; Q8N7F2; Q9NTB3;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=NUT family member 1 {ECO:0000305};
DE AltName: Full=Nuclear protein in testis;
GN Name=NUTM1 {ECO:0000312|HGNC:HGNC:29919}; Synonyms=C15orf55, NUT;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISEASE, CHROMOSOMAL TRANSLOCATION
RP WITH BRD4, TISSUE SPECIFICITY, AND VARIANT LEU-22.
RC TISSUE=Carcinoma, and Testis;
RX PubMed=12543779;
RA French C.A., Miyoshi I., Kubonishi I., Grier H.E., Perez-Atayde A.R.,
RA Fletcher J.A.;
RT "BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma.";
RL Cancer Res. 63:304-307(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), AND VARIANT
RP LEU-22.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LEU-22.
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT LEU-22.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 890-1132 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP CHROMOSOMAL TRANSLOCATION WITH BRD3, SUBCELLULAR LOCATION, AND
RP PHOSPHORYLATION AT SER-1026; SER-1029 AND SER-1031.
RX PubMed=17934517; DOI=10.1038/sj.onc.1210852;
RA French C.A., Ramirez C.L., Kolmakova J., Hickman T.T., Cameron M.J.,
RA Thyne M.E., Kutok J.L., Toretsky J.A., Tadavarthy A.K., Kees U.R.,
RA Fletcher J.A., Aster J.C.;
RT "BRD-NUT oncoproteins: a family of closely related nuclear proteins that
RT block epithelial differentiation and maintain the growth of carcinoma
RT cells.";
RL Oncogene 27:2237-2242(2008).
RN [8]
RP METHYLATION AT GLN-1046, AND MUTAGENESIS OF GLN-1046.
RX PubMed=26797129; DOI=10.1074/jbc.m115.711952;
RA Kusevic D., Kudithipudi S., Jeltsch A.;
RT "Substrate specificity of the HEMK2 protein glutamine methyltransferase and
RT identification of novel substrates.";
RL J. Biol. Chem. 291:6124-6133(2016).
RN [9]
RP FUNCTION.
RX PubMed=30447097; DOI=10.1111/cas.13884;
RA Amisaki M., Tsuchiya H., Sakabe T., Fujiwara Y., Shiota G.;
RT "Identification of genes involved in the regulation of TERT in
RT hepatocellular carcinoma.";
RL Cancer Sci. 110:550-560(2019).
CC -!- FUNCTION: Plays a role in the regulation of proliferation. Regulates
CC TERT expression by modulating SP1 binding to TERT promoter binding
CC sites. {ECO:0000269|PubMed:30447097}.
CC -!- INTERACTION:
CC Q86Y26; P09917: ALOX5; NbExp=4; IntAct=EBI-10178410, EBI-79934;
CC Q86Y26; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-10178410, EBI-10175300;
CC Q86Y26; Q3B820: FAM161A; NbExp=3; IntAct=EBI-10178410, EBI-719941;
CC Q86Y26; Q96EW2: HSPBAP1; NbExp=3; IntAct=EBI-10178410, EBI-720457;
CC Q86Y26; Q8IZ03: IFIT2; NbExp=3; IntAct=EBI-10178410, EBI-746217;
CC Q86Y26; Q7Z3B3: KANSL1; NbExp=3; IntAct=EBI-10178410, EBI-740244;
CC Q86Y26; P52292: KPNA2; NbExp=3; IntAct=EBI-10178410, EBI-349938;
CC Q86Y26; Q68G74: LHX8; NbExp=3; IntAct=EBI-10178410, EBI-8474075;
CC Q86Y26; P25800: LMO1; NbExp=3; IntAct=EBI-10178410, EBI-8639312;
CC Q86Y26; P25791: LMO2; NbExp=3; IntAct=EBI-10178410, EBI-739696;
CC Q86Y26; Q8TAP4: LMO3; NbExp=3; IntAct=EBI-10178410, EBI-742259;
CC Q86Y26; Q8NDC4: MORN4; NbExp=3; IntAct=EBI-10178410, EBI-10269566;
CC Q86Y26; O76041: NEBL; NbExp=3; IntAct=EBI-10178410, EBI-2880203;
CC Q86Y26; Q7Z4N8: P4HA3; NbExp=4; IntAct=EBI-10178410, EBI-10181968;
CC Q86Y26; P54646: PRKAA2; NbExp=3; IntAct=EBI-10178410, EBI-1383852;
CC Q86Y26; Q14997: PSME4; NbExp=3; IntAct=EBI-10178410, EBI-1236916;
CC Q86Y26; Q9NPQ8-4: RIC8A; NbExp=3; IntAct=EBI-10178410, EBI-9091816;
CC Q86Y26; Q9UPU9: SAMD4A; NbExp=3; IntAct=EBI-10178410, EBI-1047497;
CC Q86Y26; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-10178410, EBI-747035;
CC Q86Y26; Q13625-3: TP53BP2; NbExp=3; IntAct=EBI-10178410, EBI-10175039;
CC Q86Y26; O75800: ZMYND10; NbExp=3; IntAct=EBI-10178410, EBI-747061;
CC Q86Y26; Q8WWA6: ZNF277; NbExp=3; IntAct=EBI-10178410, EBI-10192794;
CC Q86Y26; Q9H641; NbExp=3; IntAct=EBI-10178410, EBI-10307415;
CC Q86Y26; PRO_0000449626 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-10178410, EBI-25475874;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17934517}. Nucleus
CC {ECO:0000269|PubMed:17934517}. Note=Shuttles between nucleus and
CC cytoplasm. {ECO:0000269|PubMed:17934517}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q86Y26-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86Y26-2; Sequence=VSP_029559, VSP_029560, VSP_029561;
CC Name=3;
CC IsoId=Q86Y26-3; Sequence=VSP_055644;
CC Name=4;
CC IsoId=Q86Y26-4; Sequence=VSP_055645;
CC -!- TISSUE SPECIFICITY: Specifically expressed in testis.
CC {ECO:0000269|PubMed:12543779}.
CC -!- PTM: Methylated at Gln-1046 by N6AMT1. {ECO:0000269|PubMed:26797129}.
CC -!- PTM: Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for
CC cytoplasmic export. {ECO:0000269|PubMed:17934517}.
CC -!- DISEASE: Note=A chromosomal aberration involving NUTM1 is found in a
CC rare, aggressive, and lethal carcinoma arising in midline organs of
CC young people. Translocation t(15;19)(q14;p13) with BRD4 which produces
CC a BRD4-NUTM1 fusion protein. {ECO:0000269|PubMed:12543779}.
CC -!- DISEASE: Note=A chromosomal aberration involving NUTM1 is found in a
CC rare, aggressive, and lethal carcinoma arising in midline organs of
CC young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a
CC BRD3-NUTM1 fusion protein. {ECO:0000269|PubMed:12543779}.
CC -!- SIMILARITY: Belongs to the NUT family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO22237.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/NUTID41595ch15q14.html";
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DR EMBL; AF482429; AAO39268.1; -; mRNA.
DR EMBL; AY166680; AAO22237.1; ALT_INIT; mRNA.
DR EMBL; AK098568; BAC05337.1; -; mRNA.
DR EMBL; AK302656; BAH13770.1; -; mRNA.
DR EMBL; AK302680; BAG63912.1; -; mRNA.
DR EMBL; AC021822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC025678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471125; EAW92304.1; -; Genomic_DNA.
DR EMBL; BC114518; AAI14519.1; -; mRNA.
DR EMBL; BC114567; AAI14568.1; -; mRNA.
DR EMBL; AL137416; CAB70729.1; -; mRNA.
DR CCDS; CCDS32190.1; -. [Q86Y26-1]
DR CCDS; CCDS61584.1; -. [Q86Y26-3]
DR CCDS; CCDS61585.1; -. [Q86Y26-4]
DR PIR; T46461; T46461.
DR RefSeq; NP_001271221.1; NM_001284292.1. [Q86Y26-4]
DR RefSeq; NP_001271222.1; NM_001284293.1. [Q86Y26-3]
DR RefSeq; NP_786883.1; NM_175741.2. [Q86Y26-1]
DR AlphaFoldDB; Q86Y26; -.
DR BioGRID; 129174; 57.
DR IntAct; Q86Y26; 25.
DR MINT; Q86Y26; -.
DR STRING; 9606.ENSP00000444896; -.
DR GlyGen; Q86Y26; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q86Y26; -.
DR PhosphoSitePlus; Q86Y26; -.
DR BioMuta; NUTM1; -.
DR DMDM; 311033405; -.
DR jPOST; Q86Y26; -.
DR MassIVE; Q86Y26; -.
DR PaxDb; Q86Y26; -.
DR PeptideAtlas; Q86Y26; -.
DR PRIDE; Q86Y26; -.
DR Antibodypedia; 41965; 130 antibodies from 19 providers.
DR DNASU; 256646; -.
DR Ensembl; ENST00000333756.4; ENSP00000329448.4; ENSG00000184507.16. [Q86Y26-1]
DR Ensembl; ENST00000438749.7; ENSP00000407031.3; ENSG00000184507.16. [Q86Y26-3]
DR Ensembl; ENST00000537011.6; ENSP00000444896.1; ENSG00000184507.16. [Q86Y26-4]
DR Ensembl; ENST00000614490.4; ENSP00000478903.1; ENSG00000184507.16. [Q86Y26-1]
DR GeneID; 256646; -.
DR KEGG; hsa:256646; -.
DR MANE-Select; ENST00000537011.6; ENSP00000444896.1; NM_001284292.2; NP_001271221.2. [Q86Y26-4]
DR UCSC; uc001zif.4; human. [Q86Y26-1]
DR CTD; 256646; -.
DR DisGeNET; 256646; -.
DR GeneCards; NUTM1; -.
DR HGNC; HGNC:29919; NUTM1.
DR HPA; ENSG00000184507; Tissue enriched (testis).
DR MalaCards; NUTM1; -.
DR MIM; 608963; gene.
DR neXtProt; NX_Q86Y26; -.
DR OpenTargets; ENSG00000184507; -.
DR Orphanet; 443167; NUT midline carcinoma.
DR PharmGKB; PA162378206; -.
DR VEuPathDB; HostDB:ENSG00000184507; -.
DR eggNOG; ENOG502RSZ6; Eukaryota.
DR GeneTree; ENSGT00410000025793; -.
DR HOGENOM; CLU_009264_0_0_1; -.
DR InParanoid; Q86Y26; -.
DR OMA; PGPDCLI; -.
DR OrthoDB; 425279at2759; -.
DR PhylomeDB; Q86Y26; -.
DR TreeFam; TF337728; -.
DR PathwayCommons; Q86Y26; -.
DR SignaLink; Q86Y26; -.
DR BioGRID-ORCS; 256646; 13 hits in 1064 CRISPR screens.
DR ChiTaRS; NUTM1; human.
DR GenomeRNAi; 256646; -.
DR Pharos; Q86Y26; Tbio.
DR PRO; PR:Q86Y26; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q86Y26; protein.
DR Bgee; ENSG00000184507; Expressed in right testis and 26 other tissues.
DR Genevisible; Q86Y26; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR024310; NUT.
DR InterPro; IPR024309; NUT_N.
DR PANTHER; PTHR22879; PTHR22879; 1.
DR Pfam; PF12881; NUT; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosomal rearrangement; Cytoplasm; Methylation;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..1132
FT /note="NUT family member 1"
FT /id="PRO_0000311394"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..54
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..975
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1014
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 5..6
FT /note="Breakpoint for translocation to form BRD4-NUTM1 and
FT BRD3-NUTM1 fusion proteins"
FT MOD_RES 1026
FT /note="Phosphoserine"
FT /evidence="ECO:0000305|PubMed:17934517"
FT MOD_RES 1029
FT /note="Phosphoserine"
FT /evidence="ECO:0000305|PubMed:17934517"
FT MOD_RES 1031
FT /note="Phosphoserine"
FT /evidence="ECO:0000305|PubMed:17934517"
FT MOD_RES 1046
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000269|PubMed:26797129"
FT VAR_SEQ 1..4
FT /note="MASD -> MFQRSNQDLKLGPYRKFSALSY (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055644"
FT VAR_SEQ 1
FT /note="M -> MVVTLGPGPDCLILEASRQPQLVPKPERM (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055645"
FT VAR_SEQ 235..365
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029559"
FT VAR_SEQ 565..573
FT /note="LQPELAAPQ -> PPTNGESQC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029560"
FT VAR_SEQ 574..1132
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029561"
FT VARIANT 22
FT /note="P -> L (in dbSNP:rs374230)"
FT /evidence="ECO:0000269|PubMed:12543779,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:16572171"
FT /id="VAR_037239"
FT VARIANT 781
FT /note="T -> M (in dbSNP:rs16959028)"
FT /id="VAR_037240"
FT VARIANT 785
FT /note="V -> E (in dbSNP:rs17236868)"
FT /id="VAR_037241"
FT VARIANT 973
FT /note="T -> N (in dbSNP:rs2279683)"
FT /id="VAR_037242"
FT VARIANT 985
FT /note="P -> R (in dbSNP:rs2279684)"
FT /id="VAR_037243"
FT VARIANT 1113
FT /note="R -> H (in dbSNP:rs2279685)"
FT /id="VAR_037244"
FT MUTAGEN 1046
FT /note="Q->R: Abolishes methylation by N6AMT1."
FT /evidence="ECO:0000269|PubMed:26797129"
FT CONFLICT 332
FT /note="Y -> H (in Ref. 2; BAG63912)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1132 AA; 120314 MW; 5CB58C1B030399F4 CRC64;
MASDGASALP GPDMSMKPSA APSPSPALPF LPPTSDPPDH PPREPPPQPI MPSVFSPDNP
LMLSAFPSSL LVTGDGGPCL SGAGAGKVIV KVKTEGGSAE PSQTQNFILT QTALNSTAPG
TPCGGLEGPA PPFVTASNVK TILPSKAVGV SQEGPPGLPP QPPPPVAQLV PIVPLEKAWP
GPHGTTGEGG PVATLSKPSL GDRSKISKDV YENFRQWQRY KALARRHLSQ SPDTEALSCF
LIPVLRSLAR LKPTMTLEEG LPLAVQEWEH TSNFDRMIFY EMAERFMEFE AEEMQIQNTQ
LMNGSQGLSP ATPLKLDPLG PLASEVCQQP VYIPKKAASK TRAPRRRQRK AQRPPAPEAP
KEIPPEAVKE YVDIMEWLVG THLATGESDG KQEEEGQQQE EEGMYPDPGL LSYINELCSQ
KVFVSKVEAV IHPQFLADLL SPEKQRDPLA LIEELEQEEG LTLAQLVQKR LMALEEEEDA
EAPPSFSGAQ LDSSPSGSVE DEDGDGRLRP SPGLQGAGGA ACLGKVSSSG KRAREVHGGQ
EQALDSPRGM HRDGNTLPSP SSWDLQPELA APQGTPGPLG VERRGSGKVI NQVSLHQDGH
LGGAGPPGHC LVADRTSEAL PLCWQGGFQP ESTPSLDAGL AELAPLQGQG LEKQVLGLQK
GQQTGGRGVL PQGKEPLAVP WEGSSGAMWG DDRGTPMAQS YDQNPSPRAA GERDDVCLSP
GVWLSSEMDA VGLELPVQIE EVIESFQVEK CVTEYQEGCQ GLGSRGNISL GPGETLVPGD
TESSVIPCGG TVAAAALEKR NYCSLPGPLR ANSPPLRSKE NQEQSCETVG HPSDLWAEGC
FPLLESGDST LGSSKETLPP TCQGNLLIMG TEDASSLPEA SQEAGSRGNS FSPLLETIEP
VNILDVKDDC GLQLRVSEDT CPLNVHSYDP QGEGRVDPDL SKPKNLAPLQ ESQESYTTGT
PKATSSHQGL GSTLPRRGTR NAIVPRETSV SKTHRSADRA KGKEKKKKEA EEEDEELSNF
AYLLASKLSL SPREHPLSPH HASGGQGSQR ASHLLPAGAK GPSKLPYPVA KSGKRALAGG
PAPTEKTPHS GAQLGVPREK PLALGVVRPS QPRKRRCDSF VTGRRKKRRR SQ
