NUTM1_MOUSE
ID NUTM1_MOUSE Reviewed; 1126 AA.
AC Q8BHP2;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=NUT family member 1 {ECO:0000305};
DE AltName: Full=Nuclear protein in testis;
GN Name=Nutm1 {ECO:0000312|MGI:MGI:2661384}; Synonyms=Nut;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-973, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays a role in the regulation of proliferation. Regulates
CC TERT expression by modulating SP1 binding to TERT promoter binding
CC sites. {ECO:0000250|UniProtKB:Q86Y26}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86Y26}. Nucleus
CC {ECO:0000250|UniProtKB:Q86Y26}. Note=Shuttles between nucleus and
CC cytoplasm. {ECO:0000250|UniProtKB:Q86Y26}.
CC -!- PTM: Methylated at Gln-1042 by N6AMT1. {ECO:0000250|UniProtKB:Q86Y26}.
CC -!- PTM: Phosphorylation on Ser-1022, Ser-1025 or Ser-1027 is important for
CC cytoplasmic export. {ECO:0000250|UniProtKB:Q86Y26}.
CC -!- SIMILARITY: Belongs to the NUT family. {ECO:0000305}.
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DR EMBL; AK077049; BAC36581.1; -; mRNA.
DR EMBL; AL713853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC125332; AAI25333.1; -; mRNA.
DR EMBL; BC125334; AAI25335.1; -; mRNA.
DR CCDS; CCDS16549.1; -.
DR RefSeq; NP_766109.1; NM_172521.1.
DR AlphaFoldDB; Q8BHP2; -.
DR BioGRID; 229468; 2.
DR STRING; 10090.ENSMUSP00000048263; -.
DR iPTMnet; Q8BHP2; -.
DR PhosphoSitePlus; Q8BHP2; -.
DR PaxDb; Q8BHP2; -.
DR PRIDE; Q8BHP2; -.
DR ProteomicsDB; 293786; -.
DR Antibodypedia; 41965; 130 antibodies from 19 providers.
DR Ensembl; ENSMUST00000043970; ENSMUSP00000048263; ENSMUSG00000041358.
DR GeneID; 213765; -.
DR KEGG; mmu:213765; -.
DR UCSC; uc008loq.1; mouse.
DR CTD; 256646; -.
DR MGI; MGI:2661384; Nutm1.
DR VEuPathDB; HostDB:ENSMUSG00000041358; -.
DR eggNOG; ENOG502RSZ6; Eukaryota.
DR GeneTree; ENSGT00410000025793; -.
DR HOGENOM; CLU_009264_0_0_1; -.
DR InParanoid; Q8BHP2; -.
DR OMA; PGPDCLI; -.
DR OrthoDB; 425279at2759; -.
DR PhylomeDB; Q8BHP2; -.
DR TreeFam; TF337728; -.
DR BioGRID-ORCS; 213765; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q8BHP2; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BHP2; protein.
DR Bgee; ENSMUSG00000041358; Expressed in spermatid and 9 other tissues.
DR Genevisible; Q8BHP2; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR024310; NUT.
DR InterPro; IPR024309; NUT_N.
DR PANTHER; PTHR22879; PTHR22879; 1.
DR Pfam; PF12881; NUT; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Methylation; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..1126
FT /note="NUT family member 1"
FT /id="PRO_0000311395"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 932..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..56
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..976
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1008
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1126
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 973
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1022
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86Y26"
FT MOD_RES 1025
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86Y26"
FT MOD_RES 1027
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86Y26"
FT MOD_RES 1042
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000250|UniProtKB:Q86Y26"
SQ SEQUENCE 1126 AA; 120687 MW; 4E6938FC37970E8E CRC64;
MASDGTSPLP GPDMSMKPGT GLSPFSALPF APPPPVPPDQ PLWEPSPQPP IPPVFSPSNP
LLLSAFPSPL LVTGEGGPGP SVAGTGQVIV KVKTDVGPAE SSQTQNLIVT QTALNWIPSG
APCGSQEGPP PPRYVTASNV KTILPAVAVG VSQEGLAGLP LQVLPPAAQL APIVPLEKPW
PGTQATTMEG GPVAARKPSQ GDLAYASKGV YENYRRWQRY KVLARTHLSQ SPDVEALSCF
LIPVLRSLAR LKPTMTLEEG LPRALQEWER TSNFDRMIFY EMAEKFMEFE AEEETQIQNA
QLMNGSPGLS PIAPLKLDPP GSMVPEACQQ PVYIPKKAAS KTRAPRRRQR KPQRPPVPEA
PKEIPPEAVQ EYVDIMDGLM GSYVDTGKTE EEEEGQQEGA GMYPDPSLLS YIDELCSQEV
FVSKVEAVIH PQFLADLLSP EEQRDPLSLL EELEQEEGLN LAQLVQKRLL ALEEEDAQTP
PSCSGAQSDS SPSVSDEDED GGQRRRPSPG LQGAAGIVRI GKSASPGKQA REIHGGQEQT
LGGPAGIHKD GNNLPSPSSW DVQLELTASQ GMPVLLGMER KMSGKAIKQL SATQDGHLGR
TGSPGYYPVA DRNPEVLPCC WQEDPQHMRA PNFDVGLTEP VPLQGLGLEK QALTLQIGKR
IGGAGMLTRG REPPSVVSQK GSSRAVRGDD RGPGMLQSYS QNHSPGAAGN LDRVSLSPGL
WLSSDMGAVG LELPLQIETV IDSIQDEACR REDQALNSRN SASLGPRKNT VPKDVGNSVI
PSGGPDTTAV PEKRNPCSLP GSLMASGPGL RSKEKISKEN QALSPKTIQN PSDLWAEACP
PLLPTLVSST LGSSKDTLIP TCQGNLLIIG TQDASSLAQT SQKAESRGNL LFPLLENIDQ
VTILDVKDDS CPQPGVSKDS CLSNFNSYNL QGEGREDTVS SKPTDLVPLQ DNQESYTHET
TKLTNGQGQG STSPRWATRD AYILRETPIK EKCTSADRAK RRETEKEEED EELSNFSYLL
ASKLSLSSGG LPLSTRQASG GQGIVKTSRH STEVDDLGQP SPPPKSGKQA LVGSPATVVE
RDQQGAQFNG SGQKPLALGM AQLPQPRKRR RDGFVTSKRK KRRRSQ
