ID   NUZM_NEUCR              Reviewed;         201 AA.
AC   P19968; Q7RVC1; Q871L0;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=NADH-ubiquinone oxidoreductase 21.3 kDa subunit;
DE            EC=7.1.1.2;
GN   ORFNames=20H10.080, NCU08930;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2137337; DOI=10.1016/0006-291x(90)91942-l;
RA   Videira A., Tropschug M., Werner S.;
RT   "Primary structure, in vitro expression and import into mitochondria of a
RT   29/21-kDa subunit of complex I from Neurospora crassa.";
RL   Biochem. Biophys. Res. Commun. 166:280-285(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Transfer of electrons from NADH to the respiratory chain. The
CC       immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Complex I is composed of about 40 different subunits.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane. Note=Importation
CC       into mitochondrion is membrane potential dependent.
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DR   EMBL; M32244; AAA33570.1; -; mRNA.
DR   EMBL; BX294024; CAD70991.1; -; Genomic_DNA.
DR   EMBL; CM002240; EAA31561.1; -; Genomic_DNA.
DR   PIR; A34051; A34051.
DR   RefSeq; XP_960797.1; XM_955704.2.
DR   AlphaFoldDB; P19968; -.
DR   SMR; P19968; -.
DR   STRING; 5141.EFNCRP00000008118; -.
DR   EnsemblFungi; EAA31561; EAA31561; NCU08930.
DR   GeneID; 3876955; -.
DR   KEGG; ncr:NCU08930; -.
DR   VEuPathDB; FungiDB:NCU08930; -.
DR   HOGENOM; CLU_081626_1_0_1; -.
DR   InParanoid; P19968; -.
DR   OMA; KYPCRTF; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   InterPro; IPR016813; NADH_Ub_cplx-1_21kDa_fun.
DR   PANTHER; PTHR37325; PTHR37325; 1.
DR   PIRSF; PIRSF022976; NADH_Oxi_21kDa; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase;
KW   Reference proteome; Translocase; Ubiquinone.
FT   CHAIN           1..201
FT                   /note="NADH-ubiquinone oxidoreductase 21.3 kDa subunit"
FT                   /id="PRO_0000118737"
FT   CONFLICT        22
FT                   /note="Q -> QQ (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        114
FT                   /note="S -> T (in Ref. 1; AAA33570)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   201 AA;  21333 MW;  2CA69243970E35FD CRC64;
     MASKVVTGVV KTTAGGVVPV SQKYTVQSVG VWERIRRAFA IDPNRSNGVP LVPYNRNPSP
     GSLDPLAYDD PVTIPAGDIA DNPYWKRDAR RNYPRLSVVG QAEAVALLSV GSASHPRVEL
     VGENGSKQLV AAQEAGKTGG LAKYFEGTGV EAGKLVLAET GGLPPLPSGE KLGEGGKWDV
     YKYQLAEEPS YSEAYPCRSF S