NVL_DICDI
ID NVL_DICDI Reviewed; 867 AA.
AC Q54SY2;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Putative ribosome biogenesis ATPase nvl {ECO:0000305};
DE AltName: Full=Nuclear valosin-containing protein-like;
GN Name=nvl; ORFNames=DDB_G0282181;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Involved in ribosome biogenesis.
CC {ECO:0000250|UniProtKB:O15381}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:O15381}. Nucleus, nucleoplasm
CC {ECO:0000250|UniProtKB:O15381}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR EMBL; AAFI02000045; EAL66370.1; -; Genomic_DNA.
DR RefSeq; XP_640327.1; XM_635235.1.
DR AlphaFoldDB; Q54SY2; -.
DR SMR; Q54SY2; -.
DR STRING; 44689.DDB0237516; -.
DR PaxDb; Q54SY2; -.
DR EnsemblProtists; EAL66370; EAL66370; DDB_G0282181.
DR GeneID; 8623428; -.
DR KEGG; ddi:DDB_G0282181; -.
DR dictyBase; DDB_G0282181; nvl.
DR eggNOG; KOG0733; Eukaryota.
DR HOGENOM; CLU_000688_8_3_1; -.
DR InParanoid; Q54SY2; -.
DR OMA; RQVFMRA; -.
DR PhylomeDB; Q54SY2; -.
DR PRO; PR:Q54SY2; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005730; C:nucleolus; ISS:dictyBase.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:1990275; F:preribosome binding; IBA:GO_Central.
DR GO; GO:0032092; P:positive regulation of protein binding; ISS:UniProtKB.
DR GO; GO:0051973; P:positive regulation of telomerase activity; IBA:GO_Central.
DR GO; GO:1904749; P:regulation of protein localization to nucleolus; ISS:UniProtKB.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; ISS:dictyBase.
DR GO; GO:0042254; P:ribosome biogenesis; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR Gene3D; 1.10.10.2010; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR038100; NLV2_N_sf.
DR InterPro; IPR031996; NVL2_nucleolin-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 2.
DR Pfam; PF16725; Nucleolin_bd; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
PE 3: Inferred from homology;
KW ATP-binding; Nucleotide-binding; Nucleus; Reference proteome; Repeat;
KW Ribosome biogenesis.
FT CHAIN 1..867
FT /note="Putative ribosome biogenesis ATPase nvl"
FT /id="PRO_0000365736"
FT REGION 70..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 257..264
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 607..614
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 867 AA; 95524 MW; 83B944FC2CD846A5 CRC64;
MVNKKYTSGQ NENEKLMDRI EKLDLSESNI LNNDFITNEL RKVYPEYNRK PLKGFKQLVE
KAMNQIIKNL SSCESSENED GDNKMEESDG DDVEIISPPL PPPSSNILNE QLTSQYKQNI
KNTPPTTTTT TPAKRNRDEN IPSNVNSNNN NNNNNNAINS NTTTNNVNTP NSKPKKKLKN
SSNGNNVFQF SNNNNNNGNN KDNNLSNGLI PTINFSNLGG VESCLRDIRE HIEYPICHPE
IYSHLGVEPP RGILLHGPSG CGKTLLAKAI AGELKVPLFA ISATEITSGV SGESEARVRT
LFSNAIAQAP CIIFIDEIDA IAPKRESASK DMERRIVSQL LTCMDSLNYL SSNNSTNEPN
EQTEQQQQQQ QDIIEVDSQA TTTTTASNNN NKQQKNDFKK GHVIVIGATN RPESLDTALR
IGGRFDKEIC LGIPDQTARC KILKVITSKM RLENNFDYEE IATLTPGYVG ADINLLVKEA
ATNSVNRIFT SNLNGASSSS SSSSSSTTNI NNIGLSTELL ISKEPLEPEK LNSLYIEMID
FKKALKKVVP AAKREGFATI PNVTWDDVGA LSGVREELTN SILRPIRYPK KYKNMGIDSP
AGVLMYGPPG CGKTLLAKAI ASECQANFIS VKGPELLNKY VGESERAVRQ VFQRAAASSP
CVIFFDEFDA LAPKRGGGDG GGNQATERVV NQLLTEMDGL EKRSEVFIIA ATNRPDIIDA
AMCRPGRLDK MVYVPLPSPE ERCEILKTLT HKIPIHQDVD LIKVGTDLRC HSFSGADLSL
LVKEAANHAI SRGFDNNSTE PDTVTMEDFI FALSKIKPSV SRKDELMYDK LNNDINKSRD
KKPNNSNNIP ITNNIPITNN NNNMIIN
