ID   NX22A_DANRE             Reviewed;         269 AA.
AC   Q90481;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Homeobox protein Nkx-2.2a;
DE   AltName: Full=Homeobox protein NK-2 homolog B-A;
GN   Name=nkx2.2a; Synonyms=nk2.2, nkx2-2, nkx2.2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7600991; DOI=10.1242/dev.121.6.1755;
RA   Barth K.A., Wilson S.W.;
RT   "Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate
RT   hedgehog-1 and demarcates a zone of neuronal differentiation in the
RT   embryonic forebrain.";
RL   Development 121:1755-1768(1995).
CC   -!- FUNCTION: Transcriptional activator involved in the development of
CC       insulin-producting beta cells in the endocrine pancreas (By
CC       similarity). May also be involved in specifying diencephalic neuromeric
CC       boundaries, and in controlling the expression of genes that play a role
CC       in axonal guidance. Binds to elements within the NEUROD1 promoter (By
CC       similarity). {ECO:0000250|UniProtKB:P42586}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P42586,
CC       ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in a continuous narrow band of cells
CC       along a boundary zone demarcating the location at which two of the
CC       earliest nuclei in the brain differentiate.
CC   -!- SIMILARITY: Belongs to the NK-2 homeobox family. {ECO:0000305}.
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DR   EMBL; X85977; CAA59967.1; -; mRNA.
DR   PIR; I50504; I50504.
DR   AlphaFoldDB; Q90481; -.
DR   SMR; Q90481; -.
DR   BioGRID; 78852; 2.
DR   STRING; 7955.ENSDARP00000117693; -.
DR   PaxDb; Q90481; -.
DR   DNASU; 30697; -.
DR   Ensembl; ENSDART00000140549; ENSDARP00000117693; ENSDARG00000053298.
DR   Ensembl; ENSDART00000190007; ENSDARP00000154455; ENSDARG00000053298.
DR   ZFIN; ZDB-GENE-980526-403; nkx2.2a.
DR   eggNOG; KOG0842; Eukaryota.
DR   GeneTree; ENSGT00940000159727; -.
DR   HOGENOM; CLU_049543_0_2_1; -.
DR   InParanoid; Q90481; -.
DR   OMA; NTDNPYT; -.
DR   PhylomeDB; Q90481; -.
DR   TreeFam; TF351204; -.
DR   PRO; PR:Q90481; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 17.
DR   Bgee; ENSDARG00000053298; Expressed in posterior neural tube and 63 other tissues.
DR   ExpressionAtlas; Q90481; baseline.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0031018; P:endocrine pancreas development; IMP:ZFIN.
DR   GO; GO:0033504; P:floor plate development; IMP:ZFIN.
DR   GO; GO:0021508; P:floor plate formation; IMP:ZFIN.
DR   GO; GO:0008347; P:glial cell migration; IMP:ZFIN.
DR   GO; GO:0008045; P:motor neuron axon guidance; IMP:ZFIN.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0014044; P:Schwann cell development; IMP:ZFIN.
DR   GO; GO:0021529; P:spinal cord oligodendrocyte cell differentiation; IMP:ZFIN.
DR   GO; GO:0021530; P:spinal cord oligodendrocyte cell fate specification; IMP:ZFIN.
DR   GO; GO:0021514; P:ventral spinal cord interneuron differentiation; IGI:ZFIN.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..269
FT                   /note="Homeobox protein Nkx-2.2a"
FT                   /id="PRO_0000048932"
FT   DNA_BIND        125..184
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..130
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   269 AA;  30307 MW;  CF006285CDD33D63 CRC64;
     MSLTNTKTGF SVKDILDLPD TNDEEGSITG TEEDTEGSEA TKTPGVLVQS PLENVQNLPL
     KNPFYDNSDN PYTRWLATTD SIQYSLHGLS ANSQDTSAKS PEPSADESPD NDKETSSNGS
     DSGKKRKRRV LFSKAQTYEL ERRFRQQRYL SAPEREHLAS LIRLTPTQVK IWFQNHRYKM
     KRARAEKGME VTHLPSPRRV AVPVLVRDGK PCHTLKAQDL AATFQAGIPF SAYSAQSLQH
     MQYNAHYSAA TTPQFPTAHH LVQTQQWTW