NXF1_CAEEL
ID NXF1_CAEEL Reviewed; 628 AA.
AC Q9XVS7;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Nuclear RNA export factor 1;
GN Name=nxf-1; ORFNames=C15H11.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP CHARACTERIZATION.
RX PubMed=11142376; DOI=10.1017/s1355838200000832;
RA Tan W., Zolotukhin A.S., Bear J., Patenaude D.J., Felber B.K.;
RT "The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an
RT ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p.";
RL RNA 6:1762-1772(2000).
CC -!- FUNCTION: Involved in RNA export from the nucleus to the cytoplasm.
CC -!- SUBUNIT: Interacts with nucleoporins, Nup98, Nup153 and Nup214.
CC -!- SUBCELLULAR LOCATION: Nucleus. Note=Shuttle protein that accumulates in
CC the nucleoplasm and at the nuclear rim.
CC -!- DOMAIN: The leucine-rich repeats and the NTF2-domain are essential for
CC the export of mRNA from the nucleus. {ECO:0000250}.
CC -!- DOMAIN: The C-terminal fragment, containing the TAP domain (also called
CC UBA-like domain) and part of the NTF2-like domain, named the NPC-
CC binding domain, mediates direct interactions with nucleoporin-FG-
CC repeats and is necessary and sufficient for its localization to the
CC nuclear rim.
CC -!- DOMAIN: The RNA-binding domain is a non-canonical RNP-type domain.
CC -!- SIMILARITY: Belongs to the NXF family. {ECO:0000305}.
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DR EMBL; Z81035; CAB02734.1; -; Genomic_DNA.
DR PIR; T19316; T19316.
DR RefSeq; NP_506567.1; NM_074166.3.
DR AlphaFoldDB; Q9XVS7; -.
DR SMR; Q9XVS7; -.
DR BioGRID; 56231; 33.
DR STRING; 6239.C15H11.3a; -.
DR EPD; Q9XVS7; -.
DR PaxDb; Q9XVS7; -.
DR UCSC; C15H11.3; c. elegans.
DR WormBase; C15H11.3a; CE08180; WBGene00003834; nxf-1.
DR eggNOG; KOG3763; Eukaryota.
DR InParanoid; Q9XVS7; -.
DR OMA; FHADEEF; -.
DR OrthoDB; 1051093at2759; -.
DR PhylomeDB; Q9XVS7; -.
DR Reactome; R-CEL-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR PRO; PR:Q9XVS7; -.
DR Proteomes; UP000001940; Chromosome V.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005635; C:nuclear envelope; IDA:WormBase.
DR GO; GO:0005643; C:nuclear pore; IDA:WormBase.
DR GO; GO:0005730; C:nucleolus; IDA:WormBase.
DR GO; GO:0005654; C:nucleoplasm; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR CDD; cd14342; UBA_TAP-C; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR030217; NXF_fam.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR005637; TAP_C_dom.
DR InterPro; IPR015245; Tap_RNA-bd.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR10662; PTHR10662; 1.
DR Pfam; PF09162; Tap-RNA_bind; 1.
DR Pfam; PF03943; TAP_C; 1.
DR SMART; SM00804; TAP_C; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR SUPFAM; SSF54427; SSF54427; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50177; NTF2_DOMAIN; 1.
DR PROSITE; PS51281; TAP_C; 1.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; mRNA transport; Nucleus; Reference proteome; Repeat;
KW RNA-binding; Transport.
FT CHAIN 1..628
FT /note="Nuclear RNA export factor 1"
FT /id="PRO_0000220536"
FT DOMAIN 100..179
FT /note="RRM"
FT REPEAT 245..270
FT /note="LRR 1"
FT REPEAT 271..294
FT /note="LRR 2"
FT DOMAIN 365..526
FT /note="NTF2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00137"
FT DOMAIN 576..628
FT /note="TAP-C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00611"
FT REGION 47..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 70962 MW; 6AF6B9DE2A798A7D CRC64;
MERDGCFGNC WLRRWEKSDM NRKGFGGHRD AKQLSRTKNR FARLDPDTQS RYEDDDEPAV
PVRASLTSAS SRGRGGSSRG FGQSAASIAN TGVRNADIVY KCRATGAAKK VDAKWLIKQL
NQIIENFKPL LWTDNARGDF EWYVRDEDTA STIRANNRRV VHKESGTRVE FYTSKVPAPW
MKLKREEIEI IHRVVDKRHN AENRVLDLSN FHEDEEFKAK DMMMNLTKGN VMLTVLDHID
DKYGNIVALS LSNNRIRHLD YASALVSIAK FVMELDLSHN HISTEKELEK FAGLPVERFF
FEGNPVVESF TQRAAYISYI HQSFPRCNML DGVEVQPLVV GPDLDIHDAM PFRAGYYPNP
QIRVLVEQFV TSYFDFYDGP DGQRTRRNLH NAYDADASTF SLTIEHLRGS SHARHHNDEC
FAQYAGVSHN VLKQERFARH RASRSARGAM DIAVALSKLP TSSHMRDTFI VDVFLQSNDL
LGFTVQGLFC DGDLTQTPSP SFFSRSFLVS PRENDSVAVI SDQLFITVAS LDRLEKFKKL
YDQSIANGAA VEQVSAVQIA QIGVNGMGFD GAPALPIREE MIKAMCQFSG MIPPFSEKCL
ADCAWNFDFA CQKFNEIKSS VPAEAFAH
