ID   ARPC5_CAEEL             Reviewed;         146 AA.
AC   P91167;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Probable actin-related protein 2/3 complex subunit 5;
DE   AltName: Full=Arp2/3 complex 16 kDa subunit;
DE            Short=p16-ARC;
GN   ORFNames=C46H11.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Functions as component of the Arp2/3 complex which is
CC       involved in regulation of actin polymerization and together with an
CC       activating nucleation-promoting factor (NPF) mediates the formation of
CC       branched actin networks. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Arp2/3 complex composed of ARP2, ARP3,
CC       ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and
CC       ARPC5/p16-ARC. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARPC5 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FO080729; CCD66217.1; -; Genomic_DNA.
DR   PIR; T25640; T25640.
DR   RefSeq; NP_491506.1; NM_059105.1.
DR   AlphaFoldDB; P91167; -.
DR   SMR; P91167; -.
DR   STRING; 6239.C46H11.3; -.
DR   PaxDb; P91167; -.
DR   EnsemblMetazoa; C46H11.3.1; C46H11.3.1; WBGene00016729.
DR   GeneID; 183522; -.
DR   KEGG; cel:CELE_C46H11.3; -.
DR   UCSC; C46H11.3; c. elegans.
DR   CTD; 183522; -.
DR   WormBase; C46H11.3; CE08785; WBGene00016729; -.
DR   eggNOG; KOG3380; Eukaryota.
DR   GeneTree; ENSGT00940000169405; -.
DR   HOGENOM; CLU_101888_1_1_1; -.
DR   InParanoid; P91167; -.
DR   OMA; SACFWKV; -.
DR   OrthoDB; 1565115at2759; -.
DR   PhylomeDB; P91167; -.
DR   Reactome; R-CEL-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR   Reactome; R-CEL-3928662; EPHB-mediated forward signaling.
DR   Reactome; R-CEL-5663213; RHO GTPases Activate WASPs and WAVEs.
DR   Reactome; R-CEL-6798695; Neutrophil degranulation.
DR   Reactome; R-CEL-8856828; Clathrin-mediated endocytosis.
DR   PRO; PR:P91167; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00016729; Expressed in embryo and 2 other tissues.
DR   GO; GO:0005885; C:Arp2/3 protein complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 1.25.40.190; -; 1.
DR   InterPro; IPR006789; ARPC5.
DR   InterPro; IPR036743; ARPC5_sf.
DR   PANTHER; PTHR12644; PTHR12644; 1.
DR   Pfam; PF04699; P16-Arc; 1.
DR   PIRSF; PIRSF039096; p16-ARC; 1.
DR   SUPFAM; SSF69103; SSF69103; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..146
FT                   /note="Probable actin-related protein 2/3 complex subunit
FT                   5"
FT                   /id="PRO_0000124057"
SQ   SEQUENCE   146 AA;  16843 MW;  F6897C272F10D77A CRC64;
     MYNTDYKKYN VDIFHPAHFE DIQEESADCG PNVQEVRQFL ESNRLEYALQ SVLLNPPFGH
     SEQELKNRAV LLVAEVIHAF RQTDIEESVH KLSNENGDIL MKYIYKAMQL CSDSATCLSL
     LLWHSQLVSK FGQGSIVRVL SNRQRL