NXF2_HUMAN
ID NXF2_HUMAN Reviewed; 626 AA.
AC Q9GZY0; Q9BXU4; Q9NSS1; Q9NX66;
DT 15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 204.
DE RecName: Full=Nuclear RNA export factor 2;
DE AltName: Full=Cancer/testis antigen 39;
DE Short=CT39;
DE AltName: Full=TAP-like protein 2;
DE Short=TAPL-2;
GN Name=NXF2; Synonyms=TAPL2;
GN and
GN Name=NXF2B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND MUTAGENESIS.
RC TISSUE=Testis;
RX PubMed=11073998; DOI=10.1128/mcb.20.23.8996-9008.2000;
RA Herold A., Suyama M., Rodrigues J.P., Braun I.C., Kutay U.,
RA Carmo-Fonseca M., Bork P., Izaurralde E.;
RT "TAP (NXF1) belongs to a multigene family of putative RNA export factors
RT with a conserved modular architecture.";
RL Mol. Cell. Biol. 20:8996-9008(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal brain;
RX PubMed=11566096; DOI=10.1016/s0960-9822(01)00419-5;
RA Jun L., Frints S., Duhamel H., Herold A., Abad-Rodrigues J., Dotti C.,
RA Izaurralde E., Marynen P., Froyen G.;
RT "NXF5, a novel member of the nuclear RNA export factor family, is lost in a
RT male patient with a syndromic form of mental retardation.";
RL Curr. Biol. 11:1381-1391(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 30-626.
RC TISSUE=Testis;
RX PubMed=11279525; DOI=10.1038/86927;
RA Wang P.J., McCarrey J.R., Yang F., Page D.C.;
RT "An abundance of X-linked genes expressed in spermatogonia.";
RL Nat. Genet. 27:422-426(2001).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 98-626.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP INTERACTION WITH NXT1.
RX PubMed=10567585; DOI=10.1128/mcb.19.12.8616;
RA Black B.E., Levesque L., Holaska J.M., Wood T.C., Paschal B.M.;
RT "Identification of an NTF2-related factor that binds Ran-GTP and regulates
RT nuclear protein export.";
RL Mol. Cell. Biol. 19:8616-8624(1999).
RN [9]
RP TISSUE SPECIFICITY, AND IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.
RX PubMed=12704671; DOI=10.1002/ijc.11104;
RA Loriot A., Boon T., De Smet C.;
RT "Five new human cancer-germline genes identified among 12 genes expressed
RT in spermatogonia.";
RL Int. J. Cancer 105:371-376(2003).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP INTERACTION WITH LUZP4.
RX PubMed=25662211; DOI=10.1093/nar/gkv070;
RA Viphakone N., Cumberbatch M.G., Livingstone M.J., Heath P.R., Dickman M.J.,
RA Catto J.W., Wilson S.A.;
RT "Luzp4 defines a new mRNA export pathway in cancer cells.";
RL Nucleic Acids Res. 43:2353-2366(2015).
CC -!- FUNCTION: Involved in the export of mRNA from the nucleus to the
CC cytoplasm.
CC -!- SUBUNIT: Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with
CC nucleoporins, Nup62, Nup153 and Nup214. Interacts with LUZP4.
CC {ECO:0000269|PubMed:10567585, ECO:0000269|PubMed:25662211}.
CC -!- INTERACTION:
CC Q9GZY0; P07686: HEXB; NbExp=3; IntAct=EBI-444173, EBI-7133736;
CC Q9GZY0; Q9NPJ8-3: NXT2; NbExp=3; IntAct=EBI-444173, EBI-10698339;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm. Note=Localized
CC in the nucleoplasm and at the nuclear envelope. Shuttles between the
CC nucleus and the cytoplasm.
CC -!- TISSUE SPECIFICITY: Expressed almost exclusively in testis. Also
CC expressed in several cancers. {ECO:0000269|PubMed:12704671}.
CC -!- DOMAIN: The NTF2 domain heterodimerizes with NXT1 and NXT2. The
CC formation of NXF1/NXT1 heterodimers is required for NXF2-mediated
CC nuclear mRNA export.
CC -!- DOMAIN: The leucine-rich repeats and the NTF2-domain are essential for
CC the export of mRNA from the nucleus.
CC -!- DOMAIN: The C-terminal fragment, containing the TAP domain (also called
CC UBA-like domain) and part of the NTF2-like domain, named the NPC-
CC binding domain, mediates direct interactions with nucleoporin-FG-
CC repeats and is necessary and sufficient for localization of NXF2 to the
CC nuclear rim.
CC -!- DOMAIN: The RNA-binding domain is a non-canonical RNP-type domain.
CC -!- SIMILARITY: Belongs to the NXF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK31975.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA91154.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAB75659.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due to either intron retention or a splicing event.; Evidence={ECO:0000305};
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DR EMBL; AJ277526; CAC16588.1; -; mRNA.
DR EMBL; AJ277659; CAC20433.1; -; mRNA.
DR EMBL; AL157436; CAB75659.1; ALT_SEQ; mRNA.
DR EMBL; Z81367; CAI42026.1; -; Genomic_DNA.
DR EMBL; AL590069; CAD13494.1; -; Genomic_DNA.
DR EMBL; BC015020; AAH15020.1; -; mRNA.
DR EMBL; AF285596; AAK31975.1; ALT_INIT; mRNA.
DR EMBL; AK000423; BAA91154.1; ALT_INIT; mRNA.
DR CCDS; CCDS14497.1; -.
DR CCDS; CCDS43979.1; -.
DR RefSeq; NP_001093156.1; NM_001099686.2.
DR RefSeq; NP_071336.1; NM_022053.3.
DR AlphaFoldDB; Q9GZY0; -.
DR SMR; Q9GZY0; -.
DR BioGRID; 121026; 64.
DR BioGRID; 608771; 4.
DR ComplexPortal; CPX-2401; mRNA nuclear export factor NXF2-NXT2.
DR ComplexPortal; CPX-925; mRNA nuclear export factor complex, NXF2-NXT1.
DR IntAct; Q9GZY0; 55.
DR STRING; 9606.ENSP00000484645; -.
DR iPTMnet; Q9GZY0; -.
DR PhosphoSitePlus; Q9GZY0; -.
DR BioMuta; NXF2B; -.
DR DMDM; 20978536; -.
DR jPOST; Q9GZY0; -.
DR MassIVE; Q9GZY0; -.
DR PaxDb; Q9GZY0; -.
DR PeptideAtlas; Q9GZY0; -.
DR PRIDE; Q9GZY0; -.
DR ProteomicsDB; 80171; -.
DR Antibodypedia; 72780; 68 antibodies from 20 providers.
DR Antibodypedia; 77042; 2 antibodies from 2 providers.
DR DNASU; 56001; -.
DR Ensembl; ENST00000602195.5; ENSP00000472530.1; ENSG00000269437.7.
DR Ensembl; ENST00000604395.5; ENSP00000474659.2; ENSG00000269437.7.
DR Ensembl; ENST00000604790.2; ENSP00000474598.2; ENSG00000269405.7.
DR Ensembl; ENST00000625106.4; ENSP00000485586.2; ENSG00000269405.7.
DR GeneID; 56001; -.
DR GeneID; 728343; -.
DR KEGG; hsa:56001; -.
DR KEGG; hsa:728343; -.
DR MANE-Select; ENST00000602195.6; ENSP00000472530.1; NM_001099686.3; NP_001093156.1.
DR MANE-Select; ENST00000625106.4; ENSP00000485586.2; NM_022053.4; NP_071336.1.
DR UCSC; uc004eix.5; human.
DR CTD; 56001; -.
DR CTD; 728343; -.
DR DisGeNET; 56001; -.
DR DisGeNET; 728343; -.
DR GeneCards; NXF2; -.
DR GeneCards; NXF2B; -.
DR HGNC; HGNC:8072; NXF2.
DR HGNC; HGNC:23984; NXF2B.
DR HPA; ENSG00000269405; Group enriched (epididymis, testis).
DR HPA; ENSG00000269437; Group enriched (epididymis, testis).
DR MIM; 300315; gene.
DR neXtProt; NX_Q9GZY0; -.
DR OpenTargets; ENSG00000269405; -.
DR OpenTargets; ENSG00000269437; -.
DR PharmGKB; PA162398310; -.
DR VEuPathDB; HostDB:ENSG00000269405; -.
DR VEuPathDB; HostDB:ENSG00000269437; -.
DR eggNOG; KOG3763; Eukaryota.
DR GeneTree; ENSGT00390000007539; -.
DR HOGENOM; CLU_011280_2_0_1; -.
DR InParanoid; Q9GZY0; -.
DR OMA; RIQFFVQ; -.
DR OrthoDB; 1051093at2759; -.
DR PhylomeDB; Q9GZY0; -.
DR TreeFam; TF314566; -.
DR PathwayCommons; Q9GZY0; -.
DR Reactome; R-HSA-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR SignaLink; Q9GZY0; -.
DR BioGRID-ORCS; 56001; 97 hits in 592 CRISPR screens.
DR BioGRID-ORCS; 728343; 13 hits in 549 CRISPR screens.
DR ChiTaRS; NXF2B; human.
DR GeneWiki; NXF2; -.
DR Pharos; Q9GZY0; Tbio.
DR PRO; PR:Q9GZY0; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9GZY0; protein.
DR Bgee; ENSG00000269405; Expressed in right testis and 38 other tissues.
DR Genevisible; Q9GZY0; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0042272; C:nuclear RNA export factor complex; IPI:ComplexPortal.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006406; P:mRNA export from nucleus; NAS:UniProtKB.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0050658; P:RNA transport; ISS:UniProtKB.
DR CDD; cd14342; UBA_TAP-C; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR002075; NTF2_dom.
DR InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR030218; NXF5.
DR InterPro; IPR030217; NXF_fam.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR005637; TAP_C_dom.
DR InterPro; IPR015245; Tap_RNA-bd.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR10662; PTHR10662; 1.
DR PANTHER; PTHR10662:SF15; PTHR10662:SF15; 1.
DR Pfam; PF02136; NTF2; 1.
DR Pfam; PF09162; Tap-RNA_bind; 1.
DR Pfam; PF03943; TAP_C; 1.
DR SMART; SM00804; TAP_C; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR SUPFAM; SSF54427; SSF54427; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50177; NTF2_DOMAIN; 1.
DR PROSITE; PS51281; TAP_C; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Leucine-rich repeat; mRNA transport; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; RNA-binding; Transport.
FT CHAIN 1..626
FT /note="Nuclear RNA export factor 2"
FT /id="PRO_0000220533"
FT DOMAIN 124..203
FT /note="RRM"
FT REPEAT 271..296
FT /note="LRR 1"
FT REPEAT 297..320
FT /note="LRR 2"
FT REPEAT 321..348
FT /note="LRR 3"
FT REPEAT 349..376
FT /note="LRR 4"
FT DOMAIN 391..541
FT /note="NTF2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00137"
FT DOMAIN 570..625
FT /note="TAP-C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00611"
FT MOD_RES 34
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MUTAGEN 598
FT /note="E->A: Has no effect on FG-nucleoporin binding."
FT /evidence="ECO:0000269|PubMed:11073998"
FT MUTAGEN 599
FT /note="W->A: Suppresses FG-nucleoporin binding."
FT /evidence="ECO:0000269|PubMed:11073998"
FT MUTAGEN 600
FT /note="N->A: Has no effect on FG-nucleoporin binding."
FT /evidence="ECO:0000269|PubMed:11073998"
SQ SEQUENCE 626 AA; 71627 MW; 319CFEDF3E67A163 CRC64;
MCSTLKKCGT YRTEVAECHD HGSTFQGRKK GGSSFRDNFD KRSCHYEHGG YERPPSHCQE
NDGSVEMRDV HKDQQLRHTP YSIRCERRMK WHSEDEIRIT TWRNRKPPER KMSQNTQDGY
TRNWFKVTIP YGIKYDKAWL MNSIQSHCSD RFTPVDFHYV RNRACFFVQD ASAASALKDV
SYKIYDDENQ KICIFVNHST APYSVKNKLK PGQMEMLKLT MNKRYNVSQQ ALDLQNLRFD
PDLMGRDIDI ILNRRNCMAA TLKIIERNFP ELLSLNLCNN KLYQLDGLSD ITEKAPKVKT
LNLSKNKLES AWELGKVKGL KLEELWLEGN PLCSTFSDQS AYVSAIRDCF PKLLRLDGRE
LSAPVIVDID SSETMKPCKE NFTGSETLKH LVLQFLQQYY SIYDSGDRQG LLGAYHDEAC
FSLAIPFDPK DSAPSSLCKY FEDSRNMKTL KDPYLKGELL RRTKRDIVDS LSALPKTQHD
LSSILVDVWC QTERMLCFSV NGVFKEVEGQ SQGSVLAFTR TFIATPGSSS SLCIVNDELF
VRDASPQETQ SAFSIPVSTL SSSSEPSLSQ EQQEMVQAFS AQSGMKLEWS QKCLQDNEWN
YTRAGQAFTM LQTEGKIPAE AFKQIS
