ID   NXNL1_DANRE             Reviewed;         215 AA.
AC   A5PMF7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Nucleoredoxin-like protein 1;
GN   Name=nxnl1; ORFNames=si:ch211-114l13.8;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: Plays an important role in retinal cone photoreceptor
CC       survival (By similarity). May play a role in cone cell viability,
CC       slowing down cone degeneration, does not seem to play a role in
CC       degenerating rods (By similarity). {ECO:0000250|UniProtKB:Q8VC33}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer
CC       segment {ECO:0000250|UniProtKB:Q8VC33}.
CC   -!- SIMILARITY: Belongs to the nucleoredoxin family. {ECO:0000305}.
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DR   EMBL; BX469930; CAN87889.1; -; Genomic_DNA.
DR   RefSeq; NP_001104230.1; NM_001110760.1.
DR   AlphaFoldDB; A5PMF7; -.
DR   SMR; A5PMF7; -.
DR   STRING; 7955.ENSDARP00000117387; -.
DR   PaxDb; A5PMF7; -.
DR   Ensembl; ENSDART00000143829; ENSDARP00000117387; ENSDARG00000052035.
DR   GeneID; 567911; -.
DR   KEGG; dre:567911; -.
DR   CTD; 115861; -.
DR   ZFIN; ZDB-GENE-070424-115; nxnl1.
DR   eggNOG; KOG2501; Eukaryota.
DR   GeneTree; ENSGT00940000161246; -.
DR   HOGENOM; CLU_116457_0_0_1; -.
DR   InParanoid; A5PMF7; -.
DR   OMA; WLFLPFQ; -.
DR   OrthoDB; 1624076at2759; -.
DR   PhylomeDB; A5PMF7; -.
DR   TreeFam; TF331873; -.
DR   PRO; PR:A5PMF7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000052035; Expressed in retina and 10 other tissues.
DR   GO; GO:0001750; C:photoreceptor outer segment; IEA:UniProtKB-SubCell.
DR   GO; GO:0045494; P:photoreceptor cell maintenance; ISS:UniProtKB.
DR   InterPro; IPR029520; RdCVF.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR47109; PTHR47109; 1.
DR   Pfam; PF13905; Thioredoxin_8; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Cell projection; Reference proteome.
FT   CHAIN           1..215
FT                   /note="Nucleoredoxin-like protein 1"
FT                   /id="PRO_0000319545"
FT   DOMAIN          1..164
FT                   /note="Thioredoxin; atypical"
FT   REGION          190..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   215 AA;  25133 MW;  327C8305F1B63F86 CRC64;
     MVDLFLGKVL VKNNKDRDEL DTEREIILRL QNRILMLFFG SGDSEKCQDF APTLKDFYKK
     LTDEFYVERS AQLVLLYISL DSSEEQQEKF LKELPKRCLF LPYEDPYRQE LGVMFEVRDL
     PRVVVLRPDC SVLSPNAVSE ICTLGTDCFR NWQEGAELID RNFMMNEEFD EGKMRSMTDP
     IRRIKYKVED EKKKKKKRDD DDDDDDGGGG GGPWG