NXNL1_MOUSE
ID NXNL1_MOUSE Reviewed; 217 AA.
AC Q8VC33; Q91W38;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Nucleoredoxin-like protein 1;
DE AltName: Full=Rod-derived cone viability factor;
DE Short=RdCVF;
DE AltName: Full=Thioredoxin-like protein 6;
GN Name=Nxnl1; Synonyms=Rdcvf, Txnl6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=15220920; DOI=10.1038/ng1386;
RA Leveillard T., Mohand-Said S., Lorentz O., Hicks D., Fintz A.-C.,
RA Clerin E., Simonutti M., Forster V., Cavusoglu N., Chalmel F., Dolle P.,
RA Poch O., Lambrou G., Sahel J.-A.;
RT "Identification and characterization of rod-derived cone viability
RT factor.";
RL Nat. Genet. 36:755-759(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=19843539; DOI=10.1093/hmg/ddp484;
RA Reichman S., Kalathur R.K., Lambard S., Ait-Ali N., Yang Y., Lardenois A.,
RA Ripp R., Poch O., Zack D.J., Sahel J.A., Leveillard T.;
RT "The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the
RT inner retina.";
RL Hum. Mol. Genet. 19:250-261(2010).
RN [4]
RP FUNCTION, AND INTERACTION WITH BSG.
RX PubMed=25957687; DOI=10.1016/j.cell.2015.03.023;
RA Ait-Ali N., Fridlich R., Millet-Puel G., Clerin E., Delalande F.,
RA Jaillard C., Blond F., Perrocheau L., Reichman S., Byrne L.C.,
RA Olivier-Bandini A., Bellalou J., Moyse E., Bouillaud F., Nicol X.,
RA Dalkara D., van Dorsselaer A., Sahel J.A., Leveillard T.;
RT "Rod-derived cone viability factor promotes cone survival by stimulating
RT aerobic glycolysis.";
RL Cell 161:817-832(2015).
CC -!- FUNCTION: Plays an important role in retinal cone photoreceptor
CC survival (PubMed:25957687). In association with glucose transporter
CC SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing
CC aerobic glycolysis and accelerating the entry of glucose into
CC photoreceptors (PubMed:25957687). May play a role in cone cell
CC viability, slowing down cone degeneration, does not seem to play a role
CC in degenerating rods (PubMed:15220920). {ECO:0000269|PubMed:15220920,
CC ECO:0000269|PubMed:25957687}.
CC -!- SUBUNIT: Interacts with isoform 1 of BSG.
CC {ECO:0000269|PubMed:25957687}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer
CC segment {ECO:0000269|PubMed:15220920}.
CC -!- TISSUE SPECIFICITY: Expressed in the retina (at protein level)
CC (PubMed:15220920, PubMed:19843539). Expressed predominantly by
CC photoreceptors in both the inner and outer nuclear layer (at protein
CC level) (PubMed:15220920, PubMed:19843539). Not expressed in the testis,
CC spleen, intestine, lung, cerebellum, or kidney (PubMed:15220920).
CC {ECO:0000269|PubMed:15220920, ECO:0000269|PubMed:19843539}.
CC -!- SIMILARITY: Belongs to the nucleoredoxin family. {ECO:0000305}.
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DR EMBL; BC021911; AAH21911.1; -; mRNA.
DR CCDS; CCDS40385.1; -.
DR RefSeq; NP_663573.1; NM_145598.2.
DR AlphaFoldDB; Q8VC33; -.
DR SMR; Q8VC33; -.
DR STRING; 10090.ENSMUSP00000127094; -.
DR PhosphoSitePlus; Q8VC33; -.
DR PaxDb; Q8VC33; -.
DR PRIDE; Q8VC33; -.
DR Antibodypedia; 27693; 137 antibodies from 23 providers.
DR DNASU; 234404; -.
DR Ensembl; ENSMUST00000048243; ENSMUSP00000039294; ENSMUSG00000034829.
DR Ensembl; ENSMUST00000163659; ENSMUSP00000127094; ENSMUSG00000034829.
DR GeneID; 234404; -.
DR KEGG; mmu:234404; -.
DR UCSC; uc012gfu.1; mouse.
DR CTD; 115861; -.
DR MGI; MGI:1924446; Nxnl1.
DR VEuPathDB; HostDB:ENSMUSG00000034829; -.
DR eggNOG; KOG2501; Eukaryota.
DR GeneTree; ENSGT00940000161246; -.
DR HOGENOM; CLU_116457_0_0_1; -.
DR InParanoid; Q8VC33; -.
DR OMA; WLFLPFQ; -.
DR OrthoDB; 1624076at2759; -.
DR PhylomeDB; Q8VC33; -.
DR TreeFam; TF331873; -.
DR BioGRID-ORCS; 234404; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8VC33; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8VC33; protein.
DR Bgee; ENSMUSG00000034829; Expressed in retinal neural layer and 29 other tissues.
DR Genevisible; Q8VC33; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0001750; C:photoreceptor outer segment; IEA:UniProtKB-SubCell.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IMP:UniProtKB.
DR InterPro; IPR029520; RdCVF.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR47109; PTHR47109; 1.
DR Pfam; PF13905; Thioredoxin_8; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW Cell projection; Reference proteome.
FT CHAIN 1..217
FT /note="Nucleoredoxin-like protein 1"
FT /id="PRO_0000319544"
FT DOMAIN 1..164
FT /note="Thioredoxin"
FT REGION 188..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 217 AA; 24912 MW; 01C386A6FCAEBC28 CRC64;
MASLFSGRIL IRNNSDQDEV ETEAELSRRL ENRLVLLFFG AGACPQCQAF APVLKDFFVR
LTDEFYVLRA AQLALVYVSQ DPTEEQQDLF LRDMPEKWLF LPFHDELRRD LGRQFSVRQL
PAVVVLKPGG DVLTSDATEE IQRLGPACFA NWQEAAELLD RSFLQPEDLD EPARRSITEP
LRRRKYRVDR DVGRERGRNG RDSGDPQGDA GTRAELW
